The National Institutes of Health (NIH) has released a grants notice for a significant research initiative titled “Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)”, under the funding opportunity number PAR-24-082. Announced on December 12, 2023, this discretionary funding opportunity is part of the Gabriella Miller Kids First Pediatric Research Program, aimed at elucidating the genetic contributions to childhood cancers and structural birth defects.
The NIH is inviting applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. This initiative encourages the sequencing of existing pediatric cancer or structural birth defect cohorts to investigate the genetic etiology and the molecular basis of the associations between birth defects and increased cancer risk. The program is particularly interested in proposals that focus on cohorts of underrepresented racial and ethnic groups or aim to increase racial and ethnic representation in existing Kids First Program projects. The data generated, along with associated clinical and phenotypic data, will become part of the Kids First Data Resource Center, making it available for broader research purposes. With the application closing date set for March 13, 2024, this grant represents a significant step towards understanding and addressing pediatric health challenges.
Opportunity ID: 351450
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-082 |
| Funding Opportunity Title: | Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | |
| Expected Number of Awards: | |
| CFDA Number(s): | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 12, 2023 |
| Last Updated Date: | Dec 12, 2023 |
| Original Closing Date for Applications: | Mar 13, 2024 |
| Current Closing Date for Applications: | Mar 13, 2024 |
| Archive Date: | Apr 18, 2024 |
| Estimated Total Program Funding: | |
| Award Ceiling: | $ |
| Award Floor: | $ |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments State governments City or township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer or structural birth defect cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of structural birth defects, to study the molecular basis of the associations between birth defects and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-082.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact: NIH Grants Information
grantsinfo@nih.gov |