Opportunity ID: 271196

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-RM-14-019
Funding Opportunity Title: Science of Behavior Change: Assay Development and Validation for Stress Reactivity and Stress Resilience Targets (UH2/UH3)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
Assistance Listings: 93.310 — Trans-NIH Research Support
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Jan 08, 2015
Last Updated Date:
Original Closing Date for Applications: Mar 20, 2015
Current Closing Date for Applications: Mar 20, 2015
Archive Date: Apr 20, 2015
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
County governments
City or township governments
Special district governments
Public and State controlled institutions of higher education
State governments
Independent school districts
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
For profit organizations other than small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress.

This Phased Innovation Awards Cooperative Agreement Funding Opportunity Announcement (FOA) solicits applications to support a collaborative research infrastructure involving an interdisciplinary team of basic and clinical scientists to develop the foundation for an experimental medicine approach to behavior change. Research supported by this FOA is meant to support activities focused on behavior change targets in the domain of stress reactivity and stress resilience through four main target validation steps:

1. Identify a set of putative targets within the stress reactivity and stress resilience domain that are implicated in medical regimen adherence and at least one other health behavior;;

2. Leverage existing or develop new experimental or intervention approaches to engage identified targets;

3. Identify or develop appropriate assays (measures) to permit verification of target engagement;

4. Test the degree to which engaging identified targets produces a desired change in medical regimen adherence and at least one other health behavior. While testing target engagement in specific clinical samples is permitted, the targets identified and the behavior change outcomes measured should be selected based on their hypothesized relevance to at least two clinical endpoints or disease conditions.

Funds from the NIH will be made available through the UH2/UH3 Phased Innovation Awards Cooperative Agreement mechanism.The initial UH2 phase will support steps 1-3 above. UH2 projects that have met their objectives and agreed upon milestones will be administratively considered by NIH and prioritized for transition to the UH3 validation phase to complete step 4 above. Projects proposed in response to this FOA will require multidisciplinary efforts and therefore all applicant teams must include expertise in basic and clinical science. Investigators responding to this FOA must address both UH2 and UH3 phases.

The output of these UH2/UH3 Target Validation Projects, to be facilitated by a Resource and Coordinating Center (RCC) funded under a companion RFA-RM-14-017, will be a toolkit of validated and documented assays of specific targets in the domain of stress reactivity and stress resilience, and experimental manipulations/interventions that engage those targets.

Please refer to the Science of Behavior Change SOBC website regularly for updates, frequently asked questions (FAQs), and other announcements related to this FOA and the companion FOAs.

SOBC Website: http://commonfund.nih.gov/behaviorchange/

FAQs: http://commonfund.nih.gov/behaviorchange/faq

Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-019.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV

Email:FBOWebmaster@OD.NIH.GOV

Version History

Version Modification Description Updated Date

Related Documents

Packages

Agency Contact Information: NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV

Email: FBOWebmaster@OD.NIH.GOV

Who Can Apply: Organization Applicants

Assistance Listing Number Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions
FORMS-C FORMS-C PKG00211482 Feb 20, 2015 Mar 20, 2015 View

Package 1

Mandatory forms

271196 RR_SF424_2_0-2.0.pdf

271196 PHS398_ResearchPlan_2_0-2.0.pdf

271196 PHS398_CoverPageSupplement_2_0-2.0.pdf

271196 RR_Budget_1_3-1.3.pdf

271196 RR_KeyPersonExpanded_2_0-2.0.pdf

271196 RR_OtherProjectInfo_1_3-1.3.pdf

271196 PerformanceSite_2_0-2.0.pdf

Optional forms

271196 PlannedReport-1.0.pdf

271196 PHS398_CumulativeInclusionReport-1.0.pdf

271196 RR_SubawardBudget30_1_3-1.3.pdf

2025-07-09T08:24:41-05:00

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