NIDDK is offering a grant to researchers interested in joining the research consortium ‘Microphysiological Systems (MPS) for Modeling Diabetes (MPS-MOD)’. The grant aims to support the development of human tissue chips that mimic key metabolic tissues for diabetes research. The platforms will measure pathophysiological changes and test known diabetes therapeutic agents. The use of isogenic/patient derived iPSC lines is crucial, as they may lead to personalized treatments and ‘clinical trials in a dish’. This grant encourages a multidisciplinary approach involving experts in stem cell biology, bioengineering, and diabetes research.
Opportunity ID: 299377
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-17-035 |
| Funding Opportunity Title: | Microphysiological Systems (MPS) for Modeling Diabetes (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 11, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 20, 2018 |
| Current Closing Date for Applications: | Mar 20, 2018 |
| Archive Date: | Apr 25, 2018 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Special district governments Native American tribal governments (Federally recognized) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education County governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | NIDDK requests applications to join a new research consortium “Microphysiological Systems (MPS) for Modeling Diabetes (MPS-MOD)”. NIDDK will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue (WAT). Experimental designs for the MPS-MOD platforms should incorporate strategies to measure pathophysiological changes associated with metabolic disease, including the impact of immune cells on metabolic dysfunction. Once developed, these multi-dimensional MPS-MOD platforms will serve as the foundation for NIDDK’s advanced strategy to identify new and novel therapeutics for diabetes. The utility and validity of model systems developed under this initiative will be measured, in part, through the ability of known diabetes therapeutic agents and biomarkers to influence biology of the system, using best practices and rigorous study design. The need for high-quality, well-characterized isogenic/patient derived iPSC (induced pluripotent stem cell) lines and standardized differentiation procedures is a critical step in turning disease-specific lines into tools for discovery. In the future, iPSC-based human tissue chips could play a central role in drug development, testing, screening, drug repurposing and toxicity testing. Eventually, collections of iPSCs that capture the heterogeneity of T2D could be used to conduct “clinical trials in a dish”, to discover biomarkers of response and to develop personalized treatments. An essential feature of this program will be a multidisciplinary approach that brings together basic science experts and physician scientists in stem cell biology, bioengineering, computational biology, pharmacology, liver biology, islet biology, adipose biology, metabolism and diabetes. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-035.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00238509 | Feb 20, 2018 | Mar 20, 2018 | View |
Package 1
Mandatory forms
299377 RR_SF424_2_0-2.0.pdf
299377 PHS398_CoverPageSupplement_4_0-4.0.pdf
299377 RR_OtherProjectInfo_1_4-1.4.pdf
299377 PerformanceSite_2_0-2.0.pdf
299377 RR_KeyPersonExpanded_2_0-2.0.pdf
299377 RR_Budget_1_4-1.4.pdf
299377 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
299377 RR_SubawardBudget30_1_4-1.4.pdf
299377 PHS_AssignmentRequestForm_2_0-2.0.pdf
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