The National Institutes of Health is offering a grant to support studies exploring Fc-dependent mechanisms of antibody-mediated killing of infected or aberrant cells, as well as therapeutic ablation in immune pathologies. This grant aims to advance research on antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP), and to develop tools and models for identifying cytotoxic mechanisms mediated by human antibodies in vivo. Applications for this grant must be submitted by January 7, 2022, and clinical trials are not allowed.
Opportunity ID: 309427
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-19-020 |
| Funding Opportunity Title: | Fc-Dependent Mechanisms of Antibody-Mediated Killing (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 05, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 07, 2022 |
| Current Closing Date for Applications: | Jan 07, 2022 |
| Archive Date: | Feb 12, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Private institutions of higher education City or township governments Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites R21 applications for studies that address knowledge gaps in mechanisms of Fc-dependent, antibody-mediated killing of infected cells or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. More specifically, the purpose of this FOA is to promote innovative and exploratory research to elucidate mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP), and to promote development of tools, technologies, and animal models to facilitate identification and evaluation of cytotoxic killing mechanisms mediated by human antibodies in vivo. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-19-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00245419 | Jan 16, 2019 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00259941 | Jan 16, 2019 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00270231 | Nov 16, 2021 | Jan 07, 2022 | View |
Package 1
Mandatory forms
309427 RR_SF424_2_0-2.0.pdf
309427 PHS398_CoverPageSupplement_4_0-4.0.pdf
309427 RR_OtherProjectInfo_1_4-1.4.pdf
309427 PerformanceSite_2_0-2.0.pdf
309427 RR_KeyPersonExpanded_2_0-2.0.pdf
309427 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
309427 RR_Budget_1_4-1.4.pdf
309427 RR_SubawardBudget30_1_4-1.4.pdf
309427 PHS398_ModularBudget_1_2-1.2.pdf
309427 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
309427 RR_SF424_2_0-2.0.pdf
309427 PHS398_CoverPageSupplement_5_0-5.0.pdf
309427 RR_OtherProjectInfo_1_4-1.4.pdf
309427 PerformanceSite_2_0-2.0.pdf
309427 RR_KeyPersonExpanded_2_0-2.0.pdf
309427 PHS398_ResearchPlan_4_0-4.0.pdf
309427 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
309427 RR_Budget_1_4-1.4.pdf
309427 RR_SubawardBudget30_1_4-1.4.pdf
309427 PHS398_ModularBudget_1_2-1.2.pdf
309427 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
309427 RR_SF424_5_0-5.0.pdf
309427 PHS398_CoverPageSupplement_5_0-5.0.pdf
309427 RR_OtherProjectInfo_1_4-1.4.pdf
309427 PerformanceSite_4_0-4.0.pdf
309427 RR_KeyPersonExpanded_4_0-4.0.pdf
309427 PHS398_ResearchPlan_4_0-4.0.pdf
309427 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
309427 RR_Budget_3_0-3.0.pdf
309427 RR_SubawardBudget30_3_0-3.0.pdf
309427 PHS398_ModularBudget_1_2-1.2.pdf
309427 PHS_AssignmentRequestForm_3_0-3.0.pdf
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