The National Institutes of Health (NIH) is offering a grant for revising active U01 research projects to expand the scope by adding new specific aims. This grant aims to foster collaborative research on metabolic reprogramming to enhance anti-tumor immune responses and manipulate tumor and immune cell metabolism for improved cancer immunotherapy. Applications should focus on understanding the metabolic processes in the tumor microenvironment, their impact on immune functions, and strategies to enhance cancer immunotherapy outcomes. The closing date for submissions is December 14, 2016.
Opportunity ID: 250860
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-14-086 |
| Funding Opportunity Title: | Revision Applications for Research on Metabolic Reprogramming to Improve Immunotherapy (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.396 — Cancer Biology Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 04, 2014 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 14, 2016 |
| Current Closing Date for Applications: | Dec 14, 2016 |
| Archive Date: | Jan 14, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites research project – cooperative agreement (U01) revision applications from investigators with active NIH U01 research project – cooperative agreement awards to support an expansion of the scope of the funded U01 research project through the addition of one or more new specific aims. Revision applications are expected to stimulate collaborative research projects to generate a mechanistic understanding of the metabolic processes that support robust anti-tumor immune responses in vivo, determine how the metabolic landscape of the tumor microenvironment affects immune effector functions, and use this information to manipulate (or reprogram) the metabolic pathways used by the tumor, the immune response, or both to improve cancer immunotherapy. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-14-086.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.396 | FORMS-C | Forms-C | PKG00192493 | Jun 10, 2014 | May 06, 2016 | View |
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00223278 | Jun 11, 2016 | Dec 14, 2016 | View |
Package 1
Mandatory forms
250860 RR_SF424_2_0-2.0.pdf
250860 PHS398_ResearchPlan_2_0-2.0.pdf
250860 PHS398_CoverPageSupplement_2_0-2.0.pdf
250860 RR_KeyPersonExpanded_2_0-2.0.pdf
250860 RR_OtherProjectInfo_1_3-1.3.pdf
250860 PerformanceSite_2_0-2.0.pdf
Optional forms
250860 RR_SubawardBudget30_1_3-1.3.pdf
250860 PlannedReport-1.0.pdf
250860 PHS398_CumulativeInclusionReport-1.0.pdf
250860 PHS398_ModularBudget_1_2-1.2.pdf
250860 RR_Budget_1_3-1.3.pdf
Package 2
Mandatory forms
250860 RR_SF424_2_0-2.0.pdf
250860 PHS398_CoverPageSupplement_3_0-3.0.pdf
250860 RR_OtherProjectInfo_1_3-1.3.pdf
250860 PerformanceSite_2_0-2.0.pdf
250860 RR_KeyPersonExpanded_2_0-2.0.pdf
250860 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
250860 RR_Budget_1_3-1.3.pdf
250860 RR_SubawardBudget30_1_3-1.3.pdf
250860 PHS398_ModularBudget_1_2-1.2.pdf
250860 PHS_Inclusion_Enrollment_Report-1.0.pdf
250860 PHS_AssignmentRequestForm-1.0.pdf
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