This grant from the National Institute on Aging is aimed at studying the impact of ApoE2 on the healthy aging process and its relationship with Alzheimer’s Disease. The focus is on understanding the protective effects of ApoE2, its interactions with aging and AD, and potential diagnostic and therapeutic implications. Research outcomes are expected to provide valuable insights into age-related cognitive disorders and offer opportunities for translational research to prevent or mitigate AD and other aging-related conditions. Applications for this grant should address the mechanistic effects of ApoE2 on aging and its potential benefits in combating neurodegenerative diseases.
Opportunity ID: 299615
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-18-022 |
| Funding Opportunity Title: | Understanding the Effects of ApoE2 on the Interaction between Aging and Alzheimers Disease (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 21, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 28, 2018 |
| Current Closing Date for Applications: | Mar 28, 2018 |
| Archive Date: | May 03, 2018 |
| Estimated Total Program Funding: | $3,000,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA invites applications on descriptive, basic and translational studies of APOE2 to delineate the functional effects of ApoE2 on healthy aging of the brain and other tissues. The primary focus is on the ApoE2-Aging-AD” relationship and the mechanistic effects of the protective variant on aging and potential interaction/crosstalk between tissues in the aging process and AD. These studies are expected to generate new mechanistic insights that involve brain and/or other organs and assist in the identification of potential prognostic and diagnostic markers and therapeutic targets for AD and other age-related cognitive disorders. Eventually, the findings from these studies could lead to translational research opportunities not only to prevent or delay the onset of AD, but also to protect against multiple age-related conditions. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-18-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00237221 | Feb 26, 2018 | Mar 28, 2018 | View |
Package 1
Mandatory forms
299615 RR_SF424_2_0-2.0.pdf
299615 PHS398_CoverPageSupplement_4_0-4.0.pdf
299615 RR_OtherProjectInfo_1_4-1.4.pdf
299615 PerformanceSite_2_0-2.0.pdf
299615 RR_KeyPersonExpanded_2_0-2.0.pdf
299615 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
299615 RR_Budget_1_4-1.4.pdf
299615 RR_SubawardBudget30_1_4-1.4.pdf
299615 PHS398_ModularBudget_1_2-1.2.pdf
299615 PHS_AssignmentRequestForm_2_0-2.0.pdf
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