This grant from the National Institutes of Health aims to support the development of innovative approaches to elucidate the impact of genetic variants on human health. By focusing on how specific variants influence function and disease processes, this program seeks to address the challenge of identifying variants of uncertain significance and their clinical implications. Researchers are encouraged to propose novel and commercializable strategies that offer insights into the relationship between genetic variation and health outcomes for improved clinical implementation. Application deadline: September 5, 2021.
Opportunity ID: 310036
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-19-043 |
| Funding Opportunity Title: | Novel Approaches for Relating Genetic Variation to Function and Disease (R43/R44 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 31, 2018 |
| Last Updated Date: | Oct 31, 2018 |
| Original Closing Date for Applications: | Sep 05, 2021 |
| Current Closing Date for Applications: | Sep 05, 2021 |
| Archive Date: | Oct 11, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Genome-wide association studies and other disease studies have identified many variants that are statistically associated with disease risk, disease protection, or other traits. However, such studies do not generally show which specific variants in genomic elements cause these effects, or how they result in differences in function. Similarly, genomic sequencing studies in clinical settings have identified many variants in healthy and diseased individuals. However, the pathogenicity of such variants is often unknown, leading to their classification as variants of uncertain significance (VUS), which makes clinical implementation difficult. This Program Announcement which has companion R21 and R01 Program Announcements aims to support the development of novel and generalizable commercialized approaches to study how genetic variants lead to differences in function and to study how such functional differences affect human health and disease processes or how this knowledge can be used clinically. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-19-043.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00246021 | Dec 05, 2018 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00260325 | Dec 05, 2018 | Sep 05, 2021 | View |
Package 1
Mandatory forms
310036 RR_SF424_2_0-2.0.pdf
310036 PHS398_CoverPageSupplement_4_0-4.0.pdf
310036 RR_OtherProjectInfo_1_4-1.4.pdf
310036 PerformanceSite_2_0-2.0.pdf
310036 RR_KeyPersonExpanded_2_0-2.0.pdf
310036 RR_Budget_1_4-1.4.pdf
310036 PHS398_ResearchPlan_4_0-4.0.pdf
310036 SBIR_STTR_Information_1_2-1.2.pdf
Optional forms
310036 RR_SubawardBudget30_1_4-1.4.pdf
310036 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
310036 RR_SF424_2_0-2.0.pdf
310036 PHS398_CoverPageSupplement_5_0-5.0.pdf
310036 RR_OtherProjectInfo_1_4-1.4.pdf
310036 PerformanceSite_2_0-2.0.pdf
310036 RR_KeyPersonExpanded_2_0-2.0.pdf
310036 RR_Budget_1_4-1.4.pdf
310036 PHS398_ResearchPlan_4_0-4.0.pdf
310036 SBIR_STTR_Information_1_3-1.3.pdf
310036 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
310036 RR_SubawardBudget30_1_4-1.4.pdf
310036 PHS_AssignmentRequestForm_3_0-3.0.pdf
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