The Department of Health and Human Services is offering the HEAL Initiative grant to establish the Hemodialysis Opioid Prescription Effort (HOPE) Consortium, aimed at addressing pain management and opioid use in Medicare End-Stage Renal Disease Hemodialysis patients. The grant focuses on developing tailored non-opioid pain treatments and evaluating the use of buprenorphine to reduce opioid dependence in the Hemodialysis population. The initiative aims to improve quality of life and mental health outcomes by implementing interventions such as Cognitive Behavioral Therapy and social media support platforms while incorporating medical interventions like naloxone. Application deadline is on Mar 27, 2019.
Opportunity ID: 310967
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-18-031 |
| Funding Opportunity Title: | HEAL Initiative: Integrated Approach to Pain and Opioid Use in Hemodialysis Patients: The Hemodialysis Opioid Prescription Effort (HOPE) Consortium – Scientific and Data Research Center (U01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2018 |
| Last Updated Date: | Dec 10, 2018 |
| Original Closing Date for Applications: | Mar 27, 2019 |
| Current Closing Date for Applications: | Mar 27, 2019 |
| Archive Date: | May 02, 2019 |
| Estimated Total Program Funding: | $5,500,000 |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Private institutions of higher education Small businesses Public and State controlled institutions of higher education City or township governments Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Pain is a common problem in Medicare End-Stage Renal Disease (ESRD) Hemodialysis (HD) patients, but its prevalence varies widely by geography, dialysis unit, and possibly, ethnicity. Perception of pain has been linked to decreased quality of life, lack of social support, depressed mood and other mental health disorders. Chronic opioid prescription has been identified in approximately 20% of US ESRD HD patients, far higher than the rate in Medicare comparison populations. Opioid doses prescribed to HD patients exceed Centers for Disease Control and Prevention (CDC) recommendations. Prescription and dose level have been associated with increased hospitalizations and mortality in this population. Interventions including behavioral modification techniques such as Cognitive Behavioral/Group Therapy and social media platforms for sharing information and enhancing social support have not been employed to reduce the rate of opioid prescription and opioid use, as well as addressing comorbid related issues such as depression, anxiety and pain in the HD population.Medical interventions such as use of naloxone and buprenorphine have not been evaluated by randomized controlled trials in HD patients who use opioids. The ESRD HD population, because of its continuous longitudinal participation in monitored treatment and the availability of data resources is an ideal population in which to launch and monitor interventions. The Hemodialysis Opioid Prescription Effort (HOPE) Consortium, composed of a Scientific and Data Research Center (SDRC) and 5 or 6 Clinical Centers (CCs) will develop an intervention to simultaneously address the problem of pain and opioid use in US HD populations a) by initiating multipronged pain treatment tailored individually to each patient, without opioids, and b) by using buprenorphine and other novel agents to reduce dependence on opioids in affected patients. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-18-031.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00246771 | Feb 27, 2019 | Mar 27, 2019 | View |
Package 1
Mandatory forms
310967 RR_SF424_2_0-2.0.pdf
310967 PHS398_CoverPageSupplement_4_0-4.0.pdf
310967 RR_OtherProjectInfo_1_4-1.4.pdf
310967 PerformanceSite_2_0-2.0.pdf
310967 RR_KeyPersonExpanded_2_0-2.0.pdf
310967 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
310967 RR_Budget_1_4-1.4.pdf
310967 RR_SubawardBudget30_1_4-1.4.pdf
310967 PHS398_ModularBudget_1_2-1.2.pdf
310967 PHS_AssignmentRequestForm_2_0-2.0.pdf
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