The Health and Human Services Department is offering a grant for projects focusing on developing targeted tolerance in Type 1 Diabetes by engineering immune responses. The aim is to establish tolerance in autoimmune-mediated dysfunction of insulin-producing beta cells. This grant encourages collaborations between T1D experts and researchers in diverse fields like cancer immunology and biomaterials engineering. Projects should investigate immune modulation strategies, such as antigen or cell manipulation, to alter the disease’s course and potentially find innovative solutions for T1D treatment. The closing date for applications is December 6, 2018.
Opportunity ID: 300701
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-17-020 |
| Funding Opportunity Title: | Immune System Engineering For Targeted Tolerance in Type 1 Diabetes (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 14, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 06, 2018 |
| Current Closing Date for Applications: | Dec 06, 2018 |
| Archive Date: | Jan 11, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education State governments County governments Special district governments Independent school districts For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Type 1 diabetes (T1D) results in part from the autoimmune-mediated dysfunction or destruction of insulin-producing pancreatic beta cells. This funding opportunity is for projects that seek to discover ways to change the course of the disease by directly establishing tolerance. Immune responses could be engineered for tolerance induction through the manipulation of antigens, cells, or cellular microenvironments. Collaborations between T1D experts and investigators from other fields, including (but not limited to) cancer immunology and biomaterials engineering, are especially encouraged. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00238283 | Apr 10, 2018 | Dec 06, 2018 | View |
Package 1
Mandatory forms
300701 RR_SF424_2_0-2.0.pdf
300701 PHS398_CoverPageSupplement_4_0-4.0.pdf
300701 RR_OtherProjectInfo_1_4-1.4.pdf
300701 PerformanceSite_2_0-2.0.pdf
300701 RR_KeyPersonExpanded_2_0-2.0.pdf
300701 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
300701 RR_Budget_1_4-1.4.pdf
300701 RR_SubawardBudget30_1_4-1.4.pdf
300701 PHS398_ModularBudget_1_2-1.2.pdf
300701 PHS_AssignmentRequestForm_2_0-2.0.pdf
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