This grant offered by the National Institute of Diabetes and Digestive and Kidney Diseases seeks to fund research in exploring human pancreatic tissues for early biomarkers of Type 1 Diabetes (T1D) pathogenesis. The focus is on identifying signaling pathways contributing to early T1D phases, developing diagnostic tools, and finding therapeutic targets for preventative treatments. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS) to better understand beta cell stress and destruction in the development of T1D, with the goal of early detection and protection of beta cell mass. Studies focusing on human disease biology are supported, with no clinical trial proposals accepted. Closing date: May 10, 2018.
Opportunity ID: 300727
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-17-021 |
| Funding Opportunity Title: | Discovery of Early Type 1 Diabetes Disease Biomarkers in the Human Pancreas [HIRN Consortium on Beta Cell Death and Survival (CBDS)] (U01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 15, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 10, 2018 |
| Current Closing Date for Applications: | May 10, 2018 |
| Archive Date: | Jun 15, 2018 |
| Estimated Total Program Funding: | $3,500,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Independent school districts State governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) requests applications to explore human pancreatic tissues for the discovery of early biomarkers of T1D pathogenesis, the description of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the development of clinical diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of detecting beta cell destruction and protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models). This FOA will not accept applications proposing a clinical trial. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-021.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or after January 25, 2018 | PKG00238305 | Apr 10, 2018 | May 10, 2018 | View |
Package 1
Mandatory forms
300727 RR_SF424_2_0-2.0.pdf
300727 PHS398_CoverPageSupplement_4_0-4.0.pdf
300727 RR_OtherProjectInfo_1_4-1.4.pdf
300727 PerformanceSite_2_0-2.0.pdf
300727 RR_KeyPersonExpanded_2_0-2.0.pdf
300727 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
300727 RR_Budget_1_4-1.4.pdf
300727 RR_SubawardBudget30_1_4-1.4.pdf
300727 PHS398_ModularBudget_1_2-1.2.pdf
300727 PHS_AssignmentRequestForm_2_0-2.0.pdf
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