The NIH is offering a grant for large-scale Functional Genomics Projects to investigate the mechanisms underlying the contribution of disease-associated variants in type 1 diabetes. This grant aims to identify causal variants, effector transcripts, and build network models to better understand the biological pathways involved in T1D. The research outcomes could lead to the development of biomarkers, improved screening methods, and personalized therapies for type 1 diabetes.
Opportunity ID: 322302
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-19-020 |
| Funding Opportunity Title: | Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Nov 06, 2019 |
| Last Updated Date: | Apr 13, 2020 |
| Original Closing Date for Applications: | Mar 26, 2020 |
| Current Closing Date for Applications: | Jun 26, 2020 |
| Archive Date: | Jul 26, 2020 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $850,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
This Funding Opportunity Announcement (FOA) encourages applications from integrative teams and individual investigators for large-scale complex multi-disciplinary Functional Genomics Projects (FGPs) to determine the contributions and mechanisms underlying the contribution of associated variants for type 1 diabetes (T1D). Genome-wide association studies (GWAS) and other genomic studies of T1D have found many variants that are statistically associated with disease risk or disease protection, but they have not clearly shown which variants in genomic elements cause these effects or how they result in differences in function. Applications submitted to this RFA will systematically identify causal variants and effector transcripts associated with all known T1D risk variants, verify the role of downstream effector transcripts, build network models that explain their role(s) in T1D. These biological insights could lead to the development of reliable biomarkers and effective strategies for screening and disease prevention, rational drug design, and better tailored therapies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Close date has been extended | Apr 13, 2020 | |
| Nov 06, 2019 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-19-020 |
| Funding Opportunity Title: | Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Nov 06, 2019 |
| Last Updated Date: | Apr 13, 2020 |
| Original Closing Date for Applications: | Mar 26, 2020 |
| Current Closing Date for Applications: | Jun 26, 2020 |
| Archive Date: | Jul 26, 2020 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $850,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
This Funding Opportunity Announcement (FOA) encourages applications from integrative teams and individual investigators for large-scale complex multi-disciplinary Functional Genomics Projects (FGPs) to determine the contributions and mechanisms underlying the contribution of associated variants for type 1 diabetes (T1D). Genome-wide association studies (GWAS) and other genomic studies of T1D have found many variants that are statistically associated with disease risk or disease protection, but they have not clearly shown which variants in genomic elements cause these effects or how they result in differences in function. Applications submitted to this RFA will systematically identify causal variants and effector transcripts associated with all known T1D risk variants, verify the role of downstream effector transcripts, build network models that explain their role(s) in T1D. These biological insights could lead to the development of reliable biomarkers and effective strategies for screening and disease prevention, rational drug design, and better tailored therapies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-19-020 |
| Funding Opportunity Title: | Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2019 |
| Last Updated Date: | Nov 06, 2019 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Mar 26, 2020 |
| Archive Date: | May 01, 2020 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $850,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Public and State controlled institutions of higher education Private institutions of higher education City or township governments For profit organizations other than small businesses County governments Small businesses Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages applications from integrative teams and individual investigators for large-scale complex multi-disciplinary Functional Genomics Projects (FGPs) to determine the contributions and mechanisms underlying the contribution of associated variants for type 1 diabetes (T1D). Genome-wide association studies (GWAS) and other genomic studies of T1D have found many variants that are statistically associated with disease risk or disease protection, but they have not clearly shown which variants in genomic elements cause these effects or how they result in differences in function. Applications submitted to this RFA will systematically identify causal variants and effector transcripts associated with all known T1D risk variants, verify the role of downstream effector transcripts, build network models that explain their role(s) in T1D. These biological insights could lead to the development of reliable biomarkers and effective strategies for screening and disease prevention, rational drug design, and better tailored therapies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00256479 | Feb 26, 2020 | Jun 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00259290 | Feb 26, 2020 | Apr 14, 2020 | View |
Package 1
Mandatory forms
322302 RR_SF424_2_0-2.0.pdf
322302 PHS398_CoverPageSupplement_4_0-4.0.pdf
322302 RR_OtherProjectInfo_1_4-1.4.pdf
322302 PerformanceSite_2_0-2.0.pdf
322302 RR_KeyPersonExpanded_2_0-2.0.pdf
322302 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
322302 RR_Budget_1_4-1.4.pdf
322302 RR_SubawardBudget30_1_4-1.4.pdf
322302 PHS398_ModularBudget_1_2-1.2.pdf
322302 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
322302 RR_SF424_2_0-2.0.pdf
322302 PHS398_CoverPageSupplement_5_0-5.0.pdf
322302 RR_OtherProjectInfo_1_4-1.4.pdf
322302 PerformanceSite_2_0-2.0.pdf
322302 RR_KeyPersonExpanded_2_0-2.0.pdf
322302 PHS398_ResearchPlan_4_0-4.0.pdf
322302 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
322302 RR_Budget_1_4-1.4.pdf
322302 RR_SubawardBudget30_1_4-1.4.pdf
322302 PHS398_ModularBudget_1_2-1.2.pdf
322302 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
