The Department of Health is offering the Friend or Foe (FoF) grant to develop a technology capable of quickly identifying potential bacterial pathogens in complex environments by analyzing their behavior. This program aims to address the increasing danger posed by emerging pathogens and those designed to evade detection. The innovative capability produced by FoF will enable high-throughput characterization of unknown bacteria based on their pathogenic traits, providing early detection of bacterial threats to public health.
Opportunity ID: 300896
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001118S0025 |
| Funding Opportunity Title: | Friend or Foe |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 10 |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Feb 16, 2018 |
| Last Updated Date: | Mar 14, 2018 |
| Original Closing Date for Applications: | Apr 25, 2018 4:00 PM ET |
| Current Closing Date for Applications: | Apr 25, 2018 4:00 PM ET |
| Archive Date: | May 25, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | The Friend or Foe (FoF) program will develop the capability to rapidly identify potential bacterial pathogens in complex environments through analysis of their behavior (i.e., their phenotype). New pathogens, both naturally occurring and adversary-engineered, are increasingly likely to emerge due to changes in the environment, rising global population, and the wide availability of genetic engineering tools to both state and non-state actors. These factors, coupled with faster potential dispersal due to increasing global travel and population density, have significantly increased the danger posed by bacterial pathogens. Current detection strategies based on biochemical markers would not work on previously undiscovered bacteria or on bacteria designed to evade detection. Moreover, genetic sequencing and omics analyses are insufficient to address this growing challenge, since the phenotype of a pathogen might not be determinable from the genetic make-up (i.e., the genotype) alone. The novel capability developed under FoF will provide detailed, high-throughput phenotype-based characterization of unknown bacteria through identification of pathogenic traits. Specifically, the technology should reliably extract representative samples of bacteria from complex environments, maintain their viability while they are repeatedly interrogated to identify virulence factors, and then analyze them using an omics approach that leverages external pathogen and gene databases. Ultimately, this technology will detect bacterial pathogens as, or even before, they emerge as a threat to the public. |
| Link to Additional Information: | FedBizOps Link |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:FriendorFoe@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| The purpose of Amendment 1 to HR001118S0025, the Friend or Foe Broad Agency Announcement, is to revise Section 4.2.4 as described in the Amendment Attachment identifying additional mandatory files to be submitted with the proposal. | Mar 14, 2018 | |
| Mar 14, 2018 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001118S0025 |
| Funding Opportunity Title: | Friend or Foe |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 10 |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Feb 16, 2018 |
| Last Updated Date: | Mar 14, 2018 |
| Original Closing Date for Applications: | Apr 25, 2018 4:00 PM ET |
| Current Closing Date for Applications: | Apr 25, 2018 4:00 PM ET |
| Archive Date: | May 25, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | The Friend or Foe (FoF) program will develop the capability to rapidly identify potential bacterial pathogens in complex environments through analysis of their behavior (i.e., their phenotype). New pathogens, both naturally occurring and adversary-engineered, are increasingly likely to emerge due to changes in the environment, rising global population, and the wide availability of genetic engineering tools to both state and non-state actors. These factors, coupled with faster potential dispersal due to increasing global travel and population density, have significantly increased the danger posed by bacterial pathogens. Current detection strategies based on biochemical markers would not work on previously undiscovered bacteria or on bacteria designed to evade detection. Moreover, genetic sequencing and omics analyses are insufficient to address this growing challenge, since the phenotype of a pathogen might not be determinable from the genetic make-up (i.e., the genotype) alone. The novel capability developed under FoF will provide detailed, high-throughput phenotype-based characterization of unknown bacteria through identification of pathogenic traits. Specifically, the technology should reliably extract representative samples of bacteria from complex environments, maintain their viability while they are repeatedly interrogated to identify virulence factors, and then analyze them using an omics approach that leverages external pathogen and gene databases. Ultimately, this technology will detect bacterial pathogens as, or even before, they emerge as a threat to the public. |
| Link to Additional Information: | FedBizOps Link |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:FriendorFoe@darpa.mil |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | HR001118S0025 |
| Funding Opportunity Title: | Friend or Foe |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 10 |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 14, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Apr 25, 2018 4:00 PM ET |
| Archive Date: | May 25, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Biological Technologies Office |
| Description: | The Friend or Foe (FoF) program will develop the capability to rapidly identify potential bacterial pathogens in complex environments through analysis of their behavior (i.e., their phenotype). New pathogens, both naturally occurring and adversary-engineered, are increasingly likely to emerge due to changes in the environment, rising global population, and the wide availability of genetic engineering tools to both state and non-state actors. These factors, coupled with faster potential dispersal due to increasing global travel and population density, have significantly increased the danger posed by bacterial pathogens. Current detection strategies based on biochemical markers would not work on previously undiscovered bacteria or on bacteria designed to evade detection. Moreover, genetic sequencing and omics analyses are insufficient to address this growing challenge, since the phenotype of a pathogen might not be determinable from the genetic make-up (i.e., the genotype) alone. The novel capability developed under FoF will provide detailed, high-throughput phenotype-based characterization of unknown bacteria through identification of pathogenic traits. Specifically, the technology should reliably extract representative samples of bacteria from complex environments, maintain their viability while they are repeatedly interrogated to identify virulence factors, and then analyze them using an omics approach that leverages external pathogen and gene databases. Ultimately, this technology will detect bacterial pathogens as, or even before, they emerge as a threat to the public. |
| Link to Additional Information: | FedBizOps Link |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:FriendorFoe@darpa.mil |
Related Documents
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> RR_PersonalData_1_2-V1.2.pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> RR_KeyPersonExpanded_2_0-V2.0.pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> HR001118S0025 Amendment 1.pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> Attachment 2_HR001118S0025-SOW_Template.pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> Attachment 3_HR001118S0025 – Budget Template.pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> Friend or Foe BAAM (CMO).pdf
Folder 300896 Full Announcement-HR001118S0025 Friend Or Foe -> Attachment 1_HR001118S0025-Executive Summary Slide Template.pdf
Packages
| Agency Contact Information: | BAA Coordinator Email: FriendorFoe@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00238683 | Feb 16, 2018 | Apr 25, 2018 | View |
Package 1
Mandatory forms
300896 RR_SF424_2_0-2.0.pdf
300896 RR_KeyPersonExpanded_2_0-2.0.pdf
300896 RR_PersonalData_1_2-1.2.pdf
Optional forms
300896 AttachmentForm_1_2-1.2.pdf
300896 RR_OtherProjectInfo_1_4-1.4.pdf
300896 PerformanceSite_2_0-2.0.pdf
300896 SFLLL_1_2-1.2.pdf
300896 RR_SubawardBudget_1_4-1.4.pdf
300896 RR_Budget_1_4-1.4.pdf
300896 Project_Abstract_1_2-1.2.pdf
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