NIA is offering a grant opportunity to support the development of PET radioligands that identify proteinopathies or pathological processes related to Alzheimer’s disease related dementias (ADRDs). This grant will fund activities such as in vitro screening of ligands, medicinal chemistry support, screening in animal models, radioligand formulation, and initial testing in humans. Applicants must have specific cores and research projects addressing ligand screening against ADRD tissue and animal models. The grant aims to address challenges in ADRDs as per the 2016 update to the National Plan to Address Alzheimer’s Disease. Closing date for applications is May 08, 2018.
Opportunity ID: 301175
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-18-025 |
| Funding Opportunity Title: | Center without Walls for PET Ligand Development for Alzheimer’s disease related dementias (ADRDs) (U19 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 02, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 08, 2018 |
| Current Closing Date for Applications: | May 08, 2018 |
| Archive Date: | Jun 13, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments City or township governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Private institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement(FOA) supports the development of PET radioligands that identify proteinopathies or pathological processes associated with the human biology of Alzheimer’s disease related dementias (ADRDs). Activities supported under this FOA include, but are not limited to the in vitro screening of existing ligands against human ADRD brain tissue, medicinal chemistry support for improvement of ligand specificity and selectivity, initial screening of ligands in appropriated animal models, and radioligand formulation and first-in-human testing. Applications must include an administrative core, a medicinal chemistry core, a clincial core, a scientific governance structure, and a minimum of two research projects with milestone plans that address workflows for screening of existing and newly derived ligands against human ADRD tissue and appropriate animal models. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. This FOA is in response to the Alzheimer’s Disease Related Dementias (ADRD) challenges outlined in the 2016 update to the National Plan to Address Alzheimer’s Disease. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-025.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00238760 | Apr 08, 2018 | May 08, 2018 | View |
Package 1
Mandatory forms
301175 RR_SF424_2_0-2.0.pdf
301175 PHS398_CoverPageSupplement_4_0-4.0.pdf
301175 RR_OtherProjectInfo_1_4-1.4.pdf
301175 PerformanceSite_2_0-2.0.pdf
301175 RR_KeyPersonExpanded_2_0-2.0.pdf
301175 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
301175 PHS_Additional_IndirectCosts-1.0.pdf
301175 PHS_AssignmentRequestForm_2_0-2.0.pdf
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