NHGRI is offering a grant to support the research and development of the next-generation genome reference representation, aiming to capture all human genome variation. The grant seeks to establish a scalable analysis framework for open science, focusing on refining the concept of pangenome as a graph and implementing practical representations. Projects should develop software solutions that are efficient, scalable, and user-friendly to facilitate broad adoption for population-scale analysis. Emphasis is placed on open science principles, including open-source tools and robust software engineering. Funding will support multiple projects to set benchmarks and standards in genome reference representations.
Opportunity ID: 312501
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-19-003 |
| Funding Opportunity Title: | Research and Development for Genome Reference Representations (GRR) (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 30, 2019 |
| Last Updated Date: | Jan 30, 2019 |
| Original Closing Date for Applications: | Apr 02, 2019 |
| Current Closing Date for Applications: | Apr 02, 2019 |
| Archive Date: | May 08, 2019 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses City or township governments Public housing authorities/Indian housing authorities State governments County governments Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The National Human Genome Research Institute (NHGRI) seeks to support research and development for a next-generation genome reference representation. This pangenome resource will be able to capture all human genome variation and support scalable analysis in a software framework that will set a robust foundation for open science. Projects will develop improved representations for computing on the information contained within the increasing numbers of diverse genome assemblies that will make up the human reference sequence going forwards. While the high-level concept of the pangenome as a graph is well-established, further research and development is needed to refine and implement a practical representation and implementation to enable active use of population-scale variation. Software is needed that can demonstrate efficiency, scalability, computational speed, ease of use, and the ability to foster adoption of the reference and analysis tool development for a wide range of purposes. The FOA will fund multiple projects that will together help set benchmarks and standards in this domain. A primary requirement is to adhere to a high level of open science including open-source tools, standards, specifications, and robust software engineering to enable this core resource to be widely integrated in the larger community and support outside contributions. Robust design is also expected to provide a foundation for independent efforts that may have enhanced privacy and security requirements. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-19-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00247964 | Mar 02, 2019 | Apr 02, 2019 | View |
Package 1
Mandatory forms
312501 RR_SF424_2_0-2.0.pdf
312501 PHS398_CoverPageSupplement_4_0-4.0.pdf
312501 RR_OtherProjectInfo_1_4-1.4.pdf
312501 PerformanceSite_2_0-2.0.pdf
312501 RR_KeyPersonExpanded_2_0-2.0.pdf
312501 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
312501 RR_Budget_1_4-1.4.pdf
312501 RR_SubawardBudget30_1_4-1.4.pdf
312501 PHS398_ModularBudget_1_2-1.2.pdf
312501 PHS_AssignmentRequestForm_2_0-2.0.pdf
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