The Department of Defense is offering a grant to fund research focused on understanding the chronic effects of neurotrauma, particularly mild traumatic brain injury (mTBI)/concussion. The grant aims to identify mechanisms, assess comorbidities, and develop treatment strategies for long-term health improvements in Service Members and Veterans. Emphasis is placed on translational research and coordination of preclinical, clinical, and data analysis activities. Applicants studying blast-related TBI must have expertise in blast physics. The Consortium is dedicated to advancing diagnostics, biomarkers, and rehabilitative strategies to address the lasting consequences of neurotrauma. Application deadline is January 4, 2013.
Opportunity ID: 198473
General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | W81XWH-12-PHTBI-CENC |
| Funding Opportunity Title:: | DoD Psychological Health and Traumatic Brain Injury Chronic Effects of Neurotrauma Consortium Award |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Science and Technology and other Research and Development |
| Category Explanation:: | |
| Expected Number of Awards:: | 1 |
| Assistance Listings Number(s):: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Sep 06, 2012 |
| Last Updated Date:: | |
| Original Closing Date for Applications:: | Jan 04, 2013 |
| Current Closing Date for Applications:: | Jan 04, 2013 |
| Archive Date:: | Feb 03, 2013 |
| Estimated Total Program Funding:: | $ 37,175,000 |
| Award Ceiling:: | $ |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility:: |
Additional Information
| Agency Name:: | Dept. of the Army — USAMRAA |
| Description:: | Recent research has indicated that TBI, including mild TBI (mTBI)/concussion with repeated exposures, leads to neuronal changes, and cognitive, behavioral, psychological, and sensory impairments. Further, research suggests that TBI, including mTBI, leads to chronic consequences (lasting 3 months or greater) in some individuals having experienced a TBI. Three critical issues related to the chronic effects of neurotrauma (over the lifespan of the patient) remain:(1) identification and characterization of the anatomic, molecular, and physiological mechanisms;(2) evaluation of how comorbidities are associated with and exacerbated by neurotrauma; and(3) appropriate treatment and rehabilitative strategies. This Consortium effort will be dedicated to establishing a comprehensive understanding of the chronic sequelae associated with neurotrauma, primarily focused on mTBI/concussion as defined by the DoD/VA. Briefly, the DoD/VA defines mTBI as associated with normal structural imaging (excluding DTI, fMRI, etc.), loss of consciousness lasting 30 minutes or less, alteration of consciousness/mental state from a moment up to 24 hours, and post-traumatic amnesia lasting 1 day or less. (The full DoD/VA mTBI definition is provided in the General Application Instructions, Appendix 7.) A key priority of this Consortium is the development of diagnostics, including a broad range of biomarkers, and novel treatment and rehabilitative strategies to improve the long-term health and well-being of Service Members and Veterans. The Consortium will coordinate research activities, including translational preclinical and clinical studies, as well as the collection, storage, use, and analyses of data and anatomical specimens, with an emphasis on basic and preclinical studies to address the anatomic, molecular, and physiological mechanisms issues and a heavy emphasis on clinical studies to address the comorbidities issues. There must be an emphasis on and progression toward translational/clinical work over the course of the Consortium. In the case of studies involving animal models, justification of validation is required at the time of application submission. Introduction of any new animal models will require clear justification. For applications studying blast-related TBI, teams should have access to an expert in the study of blast physics. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | 12.420 |
| Competition ID: | |
| Competition Title: | |
| Opportunity Package ID: | PKG00143430 |
| Opening Date: | Sep 06, 2012 |
| Closing Date: | Jan 04, 2013 |
| Agency Contact Information:: | 301-682-5507; help@cdmrp.org |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research & Related Budget [V1.1] Research And Related Senior/Key Person Profile (Expanded) [V1.2] Attachments [V1.1] |
| optional_forms | R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] |
Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| 12.420 | PKG00143430 | Sep 06, 2012 | Jan 04, 2013 | View | 301-682-5507; help@cdmrp.org | Organization Applicants |