The National Institutes of Health is offering a grant opportunity for researchers to develop innovative assays for quantifying latent HIV reservoirs in individuals on antiretroviral therapy. Current methods are slow and resource-intensive, hindering progress towards HIV cure strategies. This grant aims to support the creation of more efficient molecular or viral outgrowth assays to accurately detect replication-competent provirus in HIV-positive individuals. Proposals should focus on improving precision and speed of quantifying latent HIV reservoirs to advance research towards curing HIV infection. Closing date for applications is November 7, 2014.
Opportunity ID: 258689
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-14-020 |
| Funding Opportunity Title: | Innovative Assays to Quantify the Latent HIV Reservoir (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 27, 2014 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 07, 2014 |
| Current Closing Date for Applications: | Nov 07, 2014 |
| Archive Date: | Dec 08, 2014 |
| Estimated Total Program Funding: | $1,300,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support research on new or improved methods for quantifying latently infected cells in HIV-positive individuals on effective antiretroviral therapy. Quantifying latent HIV reservoirs is critical to evaluating strategies to cure HIV infection in vivo. The current gold-standard method involves a limiting dilution viral outgrowth assay that is slow, resource-intensive, and relatively imprecise. A molecular assay to accurately detect replication-competent provirus, or a viral outgrowth assay with improved efficiency, would facilitate proof-of-concept studies for curing HIV infection. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00200092 | Oct 07, 2014 | Nov 07, 2014 | View |
Package 1
Mandatory forms
258689 RR_SF424_2_0-2.0.pdf
258689 PHS398_ResearchPlan_2_0-2.0.pdf
258689 PHS398_CoverPageSupplement_2_0-2.0.pdf
258689 RR_KeyPersonExpanded_2_0-2.0.pdf
258689 RR_OtherProjectInfo_1_3-1.3.pdf
258689 PerformanceSite_2_0-2.0.pdf
Optional forms
258689 RR_SubawardBudget30_1_3-1.3.pdf
258689 PlannedReport-1.0.pdf
258689 PHS398_CumulativeInclusionReport-1.0.pdf
258689 PHS398_ModularBudget_1_2-1.2.pdf
258689 RR_Budget_1_3-1.3.pdf
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