The National Cancer Institute (NCI) is offering a grant to support projects aiming to identify targets that, when inhibited, would induce synthetic lethality in cancers relying on mutant KRas alleles. The focus is on developing advanced methods for synthetic lethality screens with higher specificity, reproducibility, and activity in physiologically relevant models. Researchers will collaborate with the NCI Frederick National Laboratory for Cancer Research (FNLCR) RAS Program to target Ras-dependent cancers. Awardees will form a network to share results, validate potential targets, and contribute to the mission of finding effective treatments for Ras-dependent cancers.
Opportunity ID: 261291
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-14-314 |
| Funding Opportunity Title: | New Approaches to Synthetic Lethality for Mutant KRas-Dependent Cancers (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.396 — Cancer Biology Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 07, 2014 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 08, 2015 |
| Current Closing Date for Applications: | Jul 08, 2015 |
| Archive Date: | Aug 08, 2015 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments State governments Private institutions of higher education Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications for projects to identify targets whose inhibition would induce synthetic lethality in cancers dependent on the expression of mutant KRas alleles. Despite recent advances in understanding the structural and biological complexities of mutant Ras proteins, the development of appropriate and effective methods to inhibit mutant Ras-dependent cancers has been hindered by the inability to directly target mutant Ras and the complexity of Ras processing, effector, and regulatory networks. Through this FOA, the NCI seeks to stimulate research that uses advanced or improved approaches for synthetic lethality screens that have greater specificity, reproducibility, and activity in physiologically relevant model systems than those used previously in first generation screening approaches. This FOA serves to engage extramural investigators in the mission of the NCI Frederick National Laboratory for Cancer Research (FNLCR) RAS Program to find ways to target Ras-dependent cancers. Investigators supported by this FOA will form a network to interact closely with the FNLCR RAS Program, actively exchange results across the network, and participate in cross-validation of potential targets identified by other awardees. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-14-314.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00202704 | Oct 10, 2014 | Jul 08, 2015 | View |
Package 1
Mandatory forms
261291 RR_SF424_2_0-2.0.pdf
261291 PHS398_ResearchPlan_2_0-2.0.pdf
261291 PHS398_CoverPageSupplement_2_0-2.0.pdf
261291 RR_KeyPersonExpanded_2_0-2.0.pdf
261291 RR_OtherProjectInfo_1_3-1.3.pdf
261291 PerformanceSite_2_0-2.0.pdf
Optional forms
261291 RR_SubawardBudget30_1_3-1.3.pdf
261291 PlannedReport-1.0.pdf
261291 PHS398_CumulativeInclusionReport-1.0.pdf
261291 PHS398_ModularBudget_1_2-1.2.pdf
261291 RR_Budget_1_3-1.3.pdf
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