This grant from the National Institute on Aging aims to support a research project focused on utilizing integrative omics approaches to identify profiles associated with protection against aging conditions for enhanced therapeutics development. The grant will fund interdisciplinary teams conducting multi-omic analysis on individuals with characteristics of healthy aging, utilizing existing phenotypic data, animal models, computational tools, and bioinformatics approaches. The goal is to identify molecules associated with healthy aging and exchange data with related NIH initiatives for further analysis and collaboration. Closing date for applications is Nov 14, 2018.
Opportunity ID: 306618
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-19-011 |
| Funding Opportunity Title: | Integrative Omics to Enhance Therapeutics Development for Healthy Aging (UH2/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 27, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 14, 2018 |
| Current Closing Date for Applications: | Nov 14, 2018 |
| Archive Date: | Dec 20, 2018 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $3,300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) City or township governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts For profit organizations other than small businesses Special district governments Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) is a phased innovation initiative to facilitate multi-omics/integrative approaches to identify omics profiles associated with protection against multiple aging conditions, with exceptional health span, and to refine strategies for utilizing these profiles for therapeutics development. Specifically, a phased innovation cooperative agreement mechanism (UH2/UH3) involving an interdisciplinary research team will be used to support a single project that will conduct integrative analysis of person -specific multiple omics measurements (e.g., transcriptomics, proteomics, metabolomics) generated across multiple tissues ; the multi-omic profiling should be conducted on individuals from extensively phenotyped cohorts with substantial numbers of long-lived individuals with characteristics of exceptionally healthy aging and appropriate controls. It will also: 1) harmonize and extend the use of existing phenotypic data from these studies to apply phenomics to transcriptomic, proteomic, metabolomic findings, 2) select animal model species or strains with varying life spans for comparative omics studies and identify potential determinants of species differences in longevity and rates of disease development, 3) develop appropriate computational and analytical tools to identify omics profiles associated with exceptional longevity and healthy aging, 4) apply translational bioinformatics approaches and leverage existing publicly available drug signatures databases to identify molecules that could produce profiles associated with exceptionally healthy aging and 5) exchange data with other NIH/NIA-supported related omics activities and other public-private partnerships (e.g., Trans-Omics for Precision Medicine (TOPMed), Accelerating Medicines Partnership- Alzheimers Disease (AMP-AD) for data harmonization and analysis. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-19-011.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00243420 | Oct 14, 2018 | Nov 14, 2018 | View |
Package 1
Mandatory forms
306618 RR_SF424_2_0-2.0.pdf
306618 PHS398_CoverPageSupplement_4_0-4.0.pdf
306618 RR_OtherProjectInfo_1_4-1.4.pdf
306618 PerformanceSite_2_0-2.0.pdf
306618 RR_KeyPersonExpanded_2_0-2.0.pdf
306618 RR_Budget_1_4-1.4.pdf
306618 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
306618 RR_SubawardBudget30_1_4-1.4.pdf
306618 PHS_AssignmentRequestForm_2_0-2.0.pdf
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