The National Institutes of Health is offering grants for research aiming to enhance case finding, cascade screening, and treatment for Familial Hypercholesterolemia. This funding opportunity supports clinical trials targeting barriers to population-level implementation, exploring implementation science methodologies, developing machine learning algorithms for high-risk individual identification from EHRs, and optimizing treatment strategies. Applicants should focus on improving family-based cascade screening programs for FH, assessing uptake, cost-effectiveness, feasibility, and scalability, ultimately aiming to enhance health outcomes in this population. Application deadline is on May 7, 2021.
Opportunity ID: 326377
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-22-006 |
| Funding Opportunity Title: | Implementation Research to Improve Case Finding, Cascade Screening, and Treatment for Familial Hypercholesterolemia (FH) (R61/R33 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.233 — National Center on Sleep Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 16, 2020 |
| Last Updated Date: | Apr 16, 2020 |
| Original Closing Date for Applications: | May 07, 2021 |
| Current Closing Date for Applications: | May 07, 2021 |
| Archive Date: | Jun 12, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Independent school districts County governments Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This milestone-driven Funding Opportunity Announcement (FOA) invites applications for single-site clinical trials that: (1) address barriers that impede population-level implementation of case finding and cascade screening (i.e., blood relatives of FH index cases are systematically contacted based on their risk according to the pattern of inheritance); (2) explore implementation science methodologies to assess the uptake, cost-effectiveness, feasibility, and scalability of family-based cascade screening programs for familial hypercholesterolemia (FH); (3) develop or improve machine learning algorithms and data mining techniques to find high-risk individuals using electronic health records (EHRs); and (4) optimize treatment strategies and health outcomes. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-22-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00261085 | Feb 05, 2021 | May 07, 2021 | View |
Package 1
Mandatory forms
326377 RR_SF424_2_0-2.0.pdf
326377 PHS398_CoverPageSupplement_5_0-5.0.pdf
326377 RR_OtherProjectInfo_1_4-1.4.pdf
326377 PerformanceSite_2_0-2.0.pdf
326377 RR_KeyPersonExpanded_2_0-2.0.pdf
326377 RR_Budget_1_4-1.4.pdf
326377 PHS398_ResearchPlan_4_0-4.0.pdf
326377 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
326377 RR_SubawardBudget30_1_4-1.4.pdf
326377 PHS_AssignmentRequestForm_3_0-3.0.pdf
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