The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is offering a grant to investigate the mechanisms behind the development of obesity in people with HIV (PWH). This grant aims to uncover how HIV infection and antiretroviral therapy or pre-exposure prophylaxis impact the biology of adipocytes and adipose tissue, and their effects on metabolic processes. Research proposals should focus on the unique mechanisms contributing to obesity in PWH compared to individuals without HIV. Applications are welcome to elucidate the physiological implications of these processes, addressing the increasing prevalence of obesity-related complications in PWH.
Opportunity ID: 316505
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-19-008 |
| Funding Opportunity Title: | Adipogenesis, Adipocyte Function and Obesity Following HIV Infection, Antiretroviral Therapy, or Pre-Exposure Prophylaxis (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 29, 2019 |
| Last Updated Date: | May 29, 2019 |
| Original Closing Date for Applications: | Nov 07, 2019 |
| Current Closing Date for Applications: | Nov 07, 2019 |
| Archive Date: | Dec 13, 2019 |
| Estimated Total Program Funding: | $1,500,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education City or township governments State governments For profit organizations other than small businesses Special district governments Small businesses Independent school districts Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The prevalence of obesity is increasing in people with HIV (PWH), contributing to multiple complications associated with this condition. There is mounting evidence that there are unique mechanisms contributing to the development of obesity in PWH versus people without HIV. Furthermore, the biology of the adipocytes might be altered in overweight or obese PWH versus overweight or obese people without HIV. This FOA seeks applications to elucidate the underlying mechanisms of how HIV and antiretroviral drugs used for therapy or pre-exposure prophylaxis contribute to the development of obesity and alter adipocyte and adipose tissue function as well as the effects of these processes on metabolic and physiological processes within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00251467 | Oct 07, 2019 | Nov 07, 2019 | View |
Package 1
Mandatory forms
316505 RR_SF424_2_0-2.0.pdf
316505 PHS398_CoverPageSupplement_4_0-4.0.pdf
316505 RR_OtherProjectInfo_1_4-1.4.pdf
316505 PerformanceSite_2_0-2.0.pdf
316505 RR_KeyPersonExpanded_2_0-2.0.pdf
316505 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
316505 RR_Budget_1_4-1.4.pdf
316505 RR_SubawardBudget30_1_4-1.4.pdf
316505 PHS398_ModularBudget_1_2-1.2.pdf
316505 PHS_AssignmentRequestForm_2_0-2.0.pdf
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