The NIH Common Fund invites investigators to develop bold approaches through the Knockout Mouse Phenotyping Project (KOMP2) to produce a resource of null-mutant mice for comprehensive gene functional elucidation. This limited competition grant aims to provide informatics support, curation, analysis, and dissemination of phenotype data from knockout mouse lines. The Data Coordination Center and Database (DCCDB) will integrate data into a common database under the International Mouse Phenotyping Consortium (IMPC). The grant seeks to enhance disease model identification, understand phenotypic patterns, and gain insights into gene function. Closing date for applications is December 9, 2015.
Opportunity ID: 279545
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-15-016 |
| Funding Opportunity Title: | Limited Competition: Knockout Mouse Phenotyping Project Database (UM1) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Environment Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 07, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 09, 2015 |
| Current Closing Date for Applications: | Dec 09, 2015 |
| Archive Date: | Jan 09, 2016 |
| Estimated Total Program Funding: | $12,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Private institutions of higher education |
| Additional Information on Eligibility: |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress. The purpose of the Knockout Mouse Phenotyping Project (KOMP2) is to produce a comprehensive resource of null-mutant mice, and associated phenotype data, for the purpose of elucidating functional information for each protein-coding gene in the mammalian genome. The goal of this FOA is to provide informatics support to NIH funded projects that are performing high-throughput broad based phenotyping of mouse knock-out (KO) lines (see RFA-RM-15-017) and to coordinate with international efforts so as to integrate all data into a common database under the auspices of the International Mouse Phenotyping Consortium (IMPC). The Data Coordination Center and Database (DCCDB) will perform the curation, analysis, visualization, and dissemination of the phenotype data from the knockout lines. Curation will require integration with other data sources. Analysis will require further development and validation of statistical methods.Visualization and queries will require innovative tools to disseminate the data in a real-time environment. The ultimate goals of these efforts are to enhance the ability of the biomedical research community to identify new disease models, to better understand phenotypic patterns, and to gain a more comprehensive understanding of the underlying function of each gene. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-15-016.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00219098 | Nov 09, 2015 | Dec 09, 2015 | View |
Package 1
Mandatory forms
279545 RR_SF424_2_0-2.0.pdf
279545 PHS398_ResearchPlan_2_0-2.0.pdf
279545 PHS398_CoverPageSupplement_2_0-2.0.pdf
279545 RR_Budget_1_3-1.3.pdf
279545 RR_KeyPersonExpanded_2_0-2.0.pdf
279545 RR_OtherProjectInfo_1_3-1.3.pdf
279545 PerformanceSite_2_0-2.0.pdf
Optional forms
279545 PlannedReport-1.0.pdf
279545 PHS398_CumulativeInclusionReport-1.0.pdf
279545 RR_SubawardBudget30_1_3-1.3.pdf
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