The NIH Common Fund is offering the Knockout Mouse Phenotyping Project Grant to support the creation of a null-mutant mouse phenotype resource for each gene in mouse strain C57BL/6. Through CRISPR/Cas9 technology, researchers will generate mutant mouse lines, perform phenotyping assays, conduct quality control assessments, and cryopreserve germplasm. The goal is to produce approximately 600 null-mutant mouse lines per year, with an overall target of 3,000 lines over a five-year period. The project aims to provide valuable functional information for each protein-coding gene in the mammalian genome, contributing to a comprehensive understanding of mouse genetics and advancing genomics research.
Opportunity ID: 279570
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-15-017 |
| Funding Opportunity Title: | Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Environment Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 07, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 09, 2015 |
| Current Closing Date for Applications: | Dec 09, 2015 |
| Archive Date: | Jan 09, 2016 |
| Estimated Total Program Funding: | $85,175,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress. The purpose of this FOA is to solicit applications for research projects to make maximum progress toward the goal of producing a null-mutant mouse phenotype resource for each gene in mouse strain C57BL/6, for the purpose of elucidating functional information for each protein-coding gene in the mammalian genome. The specific objectives of this FOA are to generate mutant mouse lines using CRISPR/Cas9 technology, perform phenotyping assays, conduct quality control assessments, cryopreserve germplasm, and make mice and data readily available to the research community. The mouse is the ideal mammalian system in which to produce a functional genomics resource because of the long history and depth of understanding of mouse genetics, the sophistication of assistive reproductive technology in the mouse system, short generation times, and the low cost of working with mice in comparison to other mammals. The recent breakthroughs in CRISPR/Cas9 technology make the mouse an even more cost effective model system and will drive technology of mouse production. The goal of this FOA is to support high-throughput broad based phenotyping of approximately 600 null-mutant mouse lines per year, with an overall goal of 3,000 lines for this five-year project period of the Knockout Mouse Phenotyping Program (KOMP2). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-15-017.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00219099 | Nov 09, 2015 | Dec 09, 2015 | View |
Package 1
Mandatory forms
279570 RR_SF424_2_0-2.0.pdf
279570 PHS398_ResearchPlan_2_0-2.0.pdf
279570 PHS398_CoverPageSupplement_2_0-2.0.pdf
279570 RR_Budget_1_3-1.3.pdf
279570 RR_KeyPersonExpanded_2_0-2.0.pdf
279570 RR_OtherProjectInfo_1_3-1.3.pdf
279570 PerformanceSite_2_0-2.0.pdf
Optional forms
279570 PlannedReport-1.0.pdf
279570 PHS398_CumulativeInclusionReport-1.0.pdf
279570 RR_SubawardBudget30_1_3-1.3.pdf
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