This grant by the Department of Defense aims to fund systematic, population-based research investigating the association between Traumatic Brain Injury (TBI) and Alzheimer’s Disease (AD). Applicants must focus on characterizing the cognitive and behavioral symptoms leading to functional impairments in well-defined study cohorts. Interdisciplinary teams and the use of multiple assessment measures are encouraged. Proposals should address the overarching challenge of limited clinical studies on TBI and AD in military Veterans. Research areas include genomics/proteomics/bioinformatics and imaging strategies to study neurological changes. Notably, research involving pharmacologic interventions or drug discovery is discouraged. Applications must demonstrate access to identified study cohorts and strong preliminary data supporting the research hypotheses.
Opportunity ID: 264760
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-14-PRARP-MRFA |
| Funding Opportunity Title: | DoD Peer Reviewed Alzheimer’s Military Risk Factors Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 11, 2014 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 14, 2015 |
| Current Closing Date for Applications: | Jan 14, 2015 |
| Archive Date: | Feb 13, 2015 |
| Estimated Total Program Funding: | $5,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The intent of the FY14 Military Risk Factors Research Award (MRFA) is to facilitate high-impact, systematic, population-based research investigating the association between TBI and the subsequent development of AD. Applications should describe how the association of TBI and subsequent AD will be characterized. Applications should also describe how the proposed study will work with well-defined, already identified study cohorts. Applications should carefully consider how their studies will characterize the cognitive and behavioral symptoms that result in functional impairments in the proposed cohort. Studies that use combinations of measures (e.g., neuropsychological assessments, imaging, genomics, and cerebral spinal fluid) are encouraged. Applications that develop interdisciplinary teams or consortia as part of the support plan for executing the research are encouraged. Important Note: Applications must detail and demonstrate expedited access to a well-defined, already identified study cohort. Preliminary data that supports how the cohort will be used in the study is also required. The preliminary data must strongly support the proposed research hypothesis (or hypotheses). Refer to the Review Criteria in this Program Announcement/ Funding Opportunity for details. Overarching Challenge: This MRFA funding opportunity requires applications to address the following PRARP Overarching Challenge: Paucity of Clinical Studies: The paucity of clinical studies and other research resources to examine the interrelationship between TBI and subsequent AD for military Veterans/other individuals affected by TBI. Focus Areas: In addition to addressing the Overarching Challenge, applications must also address at least one of the following FY14 PRARP Focus Areas in support of the Overarching Challenge. An application that proposes research outside of these Focus Areas is acceptable, as long as the applicant provides a strong rationale: Genomics/Proteomics/Bioinformatics: Studies or technologies (e.g., genetic, proteomic and epigenetic strategies) intended to characterize neurological change associated with TBI and subsequent AD. In addition to studies, relevant technologies or tests may be considered under this focus area. Imaging: Development and application of anatomic and molecular imaging strategies to characterize neurological changes associated with TBI and subsequent AD While the MRFA mechanism can be used to support clinical research, the following is specifically discouraged under the FY14 PRARP: Pharmacologic Interventions: Clinical or Basic research requiring investigational or FDA-approved drugs or medicines. Drug Discovery and Development: Clinical or Basic research directly leading to the development of investigational medicines, drugs, or agents. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
Phone: 301-682-5507 Email: help@eBRAP.org Email:mail: help@eBRAP.org |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 264760 Full Announcement-1 -> PRARP_FY14 MRFA PA_GG.pdf
Packages
| Agency Contact Information: | CDMRP Help Desk Phone: 301-682-5507 Email: help@eBRAP.org Email: mail: help@eBRAP.org |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00205607 | Sep 11, 2014 | Jan 14, 2015 | View |
Package 1
Mandatory forms
264760 RR_SF424_2_0-2.0.pdf
264760 RR_Budget_1_3-1.3.pdf
264760 RR_KeyPersonExpanded_2_0-2.0.pdf
264760 PerformanceSite_2_0-2.0.pdf
Optional forms
264760 RR_SubawardBudget30_1_3-1.3.pdf
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