The Health Department is offering a grant to support rigorous pre-clinical studies that establish the rationale for clinical trials based on existing drugs or biologics. This grant aims to explore new uses of investigational, phase 2a-ready, or FDA-approved drugs by utilizing published or publicly available methods. Applicants must identify the method for identifying new therapeutic indications and describe pre-clinical studies to demonstrate the utility of independent crowdsourcing efforts or computational algorithms. The studies funded will focus on measuring quantifiable effects of the therapies to establish scientific support for novel therapeutic indications. Closing date for applications is January 13, 2016.
Opportunity ID: 279764
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-16-001 |
| Funding Opportunity Title: | Pre-clinical Research Based on Existing Repurposing Tools |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 21, 2015 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 13, 2016 |
| Current Closing Date for Applications: | Jan 13, 2016 |
| Archive Date: | Feb 13, 2016 |
| Estimated Total Program Funding: | $4,300,000 |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments County governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) For profit organizations other than small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) will support rigorous, pre-clinical studies that establish the rationale for a clinical trial, where the hypothesis originates from use of a published or publicly available method for identifying new indications for existing drugs or biologics (therapeutics). The goal of an individual project will be to explore the potential new use of an existing investigational, phase 2a-ready, or FDA-approved drug or licensed biologic; a pre-clinical study funded through this initiative will serve as a use case to demonstrate the utility of an independent crowdsourcing effort or of a computational algorithm to predict new uses of a drug or biologic. Applicants must clearly identify the published or publicly available method used to identify a novel therapeutic/indication pair or combination therapy, in addition to describing the pre-clinical studies that will serve as the use case. This use cases must have a scientifically supported rationale where objective, quantifiable effects of the therapy can be measured. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | FORMS-C | PKG00219272 | Dec 13, 2015 | Jan 13, 2016 | View |
Package 1
Mandatory forms
279764 RR_SF424_2_0-2.0.pdf
279764 PHS398_ResearchPlan_2_0-2.0.pdf
279764 PHS398_CoverPageSupplement_2_0-2.0.pdf
279764 RR_KeyPersonExpanded_2_0-2.0.pdf
279764 RR_OtherProjectInfo_1_3-1.3.pdf
279764 PerformanceSite_2_0-2.0.pdf
Optional forms
279764 RR_SubawardBudget30_1_3-1.3.pdf
279764 PlannedReport-1.0.pdf
279764 PHS398_CumulativeInclusionReport-1.0.pdf
279764 PHS398_ModularBudget_1_2-1.2.pdf
279764 RR_Budget_1_3-1.3.pdf
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