This grant, offered by the National Institutes of Health, aims to support the development of innovative approaches to bridge the gap between genetic variants and their impact on human health and disease. By focusing on understanding how genetic variations influence function and health outcomes, the grant seeks to address the challenge of interpreting variants of uncertain significance (VUS) and enhance clinical implementation of genomic research findings. Researchers are encouraged to propose novel methodologies that elucidate the functional implications of genetic variants, contributing to a deeper understanding of disease etiology and potential clinical applications.
Opportunity ID: 307498
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-18-867 |
| Funding Opportunity Title: | Novel Approaches for Relating Genetic Variation to Function and Disease (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 23, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 16, 2021 |
| Current Closing Date for Applications: | Jul 16, 2021 |
| Archive Date: | Aug 21, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Private institutions of higher education Special district governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Genome-wide association studies and other disease studies have identified many variants that are statistically associated with disease risk, disease protection, or other traits. However, such studies do not generally show which specific variants in genomic elements cause these effects, or how they result in differences in function. Similarly, genomic sequencing studies in clinical settings have identified many variants in healthy and diseased individuals. However, the pathogenicity of such variants is often unknown, leading to their classification as variants of uncertain significance (VUS), which makes clinical implementation difficult. This Program Announcement and the companion R21 Program Announcement aim to support the development of novel and generalizable approaches to study how genetic variants lead to differences in function and to study how such functional differences affect human health and disease processes or how this knowledge can be used clinically. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-18-867.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00243961 | Sep 16, 2018 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00259932 | Sep 16, 2018 | Jul 16, 2021 | View |
Package 1
Mandatory forms
307498 RR_SF424_2_0-2.0.pdf
307498 PHS398_CoverPageSupplement_4_0-4.0.pdf
307498 RR_OtherProjectInfo_1_4-1.4.pdf
307498 PerformanceSite_2_0-2.0.pdf
307498 RR_KeyPersonExpanded_2_0-2.0.pdf
307498 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
307498 RR_Budget_1_4-1.4.pdf
307498 RR_SubawardBudget30_1_4-1.4.pdf
307498 PHS398_ModularBudget_1_2-1.2.pdf
307498 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
307498 RR_SF424_2_0-2.0.pdf
307498 PHS398_CoverPageSupplement_5_0-5.0.pdf
307498 RR_OtherProjectInfo_1_4-1.4.pdf
307498 PerformanceSite_2_0-2.0.pdf
307498 RR_KeyPersonExpanded_2_0-2.0.pdf
307498 PHS398_ResearchPlan_4_0-4.0.pdf
307498 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
307498 RR_Budget_1_4-1.4.pdf
307498 RR_SubawardBudget30_1_4-1.4.pdf
307498 PHS398_ModularBudget_1_2-1.2.pdf
307498 PHS_AssignmentRequestForm_3_0-3.0.pdf
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