This grant offered by the National Institute of Health focuses on developing innovative methods to understand how genetic variations influence function and disease development. By addressing the limitations of current genomic studies, such as identifying the causative variants and their impact on biological mechanisms, this program seeks to bridge the gap between genetic research and clinical application. Researchers are encouraged to propose novel approaches that provide insights into the pathogenicity of genetic variants, ultimately aiming to improve diagnostics and treatment strategies for various diseases. Closing date for applications is July 5, 2021.
Opportunity ID: 307499
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-18-868 |
| Funding Opportunity Title: | Novel Approaches for Relating Genetic Variation to Function and Disease (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 23, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 05, 2021 |
| Current Closing Date for Applications: | Jul 05, 2021 |
| Archive Date: | Aug 10, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments Small businesses Special district governments For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Genome-wide association studies have found many variants associated with disease risk, disease protection, or other traits. However, these studies generally identify many variants that are statistically associated with the trait, but do not show which variants in genomic elements cause these effects, or how they result in differences in function. Similarly, clinical genomic sequencing studies have identified many variants in healthy and diseased individuals, but the pathogenicity of such variants is usually unknown, leading to their classification as variants of uncertain significance (VUSs), which makes clinical implementation difficult. This program aims to support the development of generalizable approaches to study how genetic variants lead to differences in function, how such functional differences lead to disease processes, and how this knowledge can be used clinically. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-18-868.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00243982 | Sep 05, 2018 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00259109 | Sep 05, 2018 | Jul 05, 2021 | View |
Package 1
Mandatory forms
307499 RR_SF424_2_0-2.0.pdf
307499 PHS398_CoverPageSupplement_4_0-4.0.pdf
307499 RR_OtherProjectInfo_1_4-1.4.pdf
307499 PerformanceSite_2_0-2.0.pdf
307499 RR_KeyPersonExpanded_2_0-2.0.pdf
307499 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
307499 RR_Budget_1_4-1.4.pdf
307499 RR_SubawardBudget30_1_4-1.4.pdf
307499 PHS398_ModularBudget_1_2-1.2.pdf
307499 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
307499 RR_SF424_2_0-2.0.pdf
307499 PHS398_CoverPageSupplement_5_0-5.0.pdf
307499 RR_OtherProjectInfo_1_4-1.4.pdf
307499 PerformanceSite_2_0-2.0.pdf
307499 RR_KeyPersonExpanded_2_0-2.0.pdf
307499 PHS398_ResearchPlan_4_0-4.0.pdf
307499 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
307499 RR_Budget_1_4-1.4.pdf
307499 RR_SubawardBudget30_1_4-1.4.pdf
307499 PHS398_ModularBudget_1_2-1.2.pdf
307499 PHS_AssignmentRequestForm_3_0-3.0.pdf
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