The NIH is offering a grant to develop innovative technologies for isolating and characterizing extracellular vesicles (EVs) derived from the Central Nervous System (CNS). The focus is on creating reliable methods for isolating CNS-EVs from peripheral samples, identifying their types, cargos, and origin, and validating these methods for comprehensive analysis of EV composition. Applicants are encouraged to enhance current techniques for studying EV RNA, proteins, lipids, and metabolites. This grant opportunity aims to advance CNS-EV research and contribute to a better understanding of neurological diseases.
Opportunity ID: 298427
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-18-600 |
| Funding Opportunity Title: | NIH Blue Print: Development and Validation of Technologies for Rapid Isolation and Characterization of Extracellular Vesicles of Central Nervous System Origin (R21/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | 6 |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 22, 2018 |
| Current Closing Date for Applications: | Jan 22, 2018 |
| Archive Date: | Feb 27, 2018 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Special district governments Independent school districts City or township governments Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages applications that will develop novel technologies and/or tools for the isolation and characterization of extracellular vesicles (EVs) of Central Nervous System (CNS) origin. The primary focus of the technology development includes robust and reproducible CNS-EV isolation methods. Specifically, there is a need to establish technologies for the isolation and purification of CNS-EVs from peripheral samples and the characterization of CNS-EV types, cargos, and origin, as well as to validate these methods for further analyses. Validation of these technologies may include the analysis of the full range of EV composition such as RNA, proteins, lipids, and metabolites. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-18-600.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00235809 | Dec 22, 2017 | Jan 27, 2018 | View |
Package 1
Mandatory forms
298427 RR_SF424_2_0-2.0.pdf
298427 PHS398_CoverPageSupplement_3_0-3.0.pdf
298427 RR_OtherProjectInfo_1_3-1.3.pdf
298427 PerformanceSite_2_0-2.0.pdf
298427 RR_KeyPersonExpanded_2_0-2.0.pdf
298427 RR_Budget_1_3-1.3.pdf
298427 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
298427 RR_SubawardBudget30_1_3-1.3.pdf
298427 PHS_Inclusion_Enrollment_Report-1.0.pdf
298427 PHS_AssignmentRequestForm-1.0.pdf
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