The NIH is offering a grant to advance research on extracellular RNA (exRNA) communication, focusing on improving the isolation and analysis of exRNA-carrier subclasses. This grant aims to develop innovative technologies for sorting biofluids into homogeneous carrier populations such as extracellular vesicles (EVs), ribonucleoproteins (RNPs), and lipoproteins (LPPs. The goal is to enable rapid and reproducible isolation and analysis of exRNA content and molecular cargo in these carriers. Applications are open until October 23, 2018, for those interested in advancing the understanding of intercellular communication through exRNAs.
Opportunity ID: 307998
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-18-027 |
| Funding Opportunity Title: | Advancing Extracellular RNA (exRNA) Communication Research: Improved Isolation and Analysis of exRNA-Carrier Subclasses (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Oct 23, 2018 |
| Current Closing Date for Applications: | Oct 23, 2018 |
| Archive Date: | Nov 28, 2018 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Special district governments City or township governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses Public and State controlled institutions of higher education Private institutions of higher education State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Circulating extracellular RNAs (exRNAs) can act as endocrine signaling molecules, both locally and systemically, representing a novel paradigm in intercellular communication. ExRNAs are transported in body fluids in association with a variety of carrier vehicles of varying complexity including extracellular vesicles (EVs), ribonucleoproteins (RNPs), and lipoproteins (LPPs). These distinct carriers protect exRNAs from degradation and are thought to contribute to the biodistribution, uptake, and functional impact of exRNAs in target cells. The overarching goal of this Funding Opportunity Announcement (FOA) is to develop and evaluate innovative separation tools, technologies, and approaches that will enable the scientific community to rapidly and reproducibly sort complex biofluids into homogenous carrier populations of EVs, (including EV subsets), RNPs, and LPPs, and that also support high-throughput isolation and analysis of their extracellular RNA content and associated molecular cargo. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-18-027.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00244265 | Sep 23, 2018 | Oct 23, 2018 | View |
Package 1
Mandatory forms
307998 RR_SF424_2_0-2.0.pdf
307998 PHS398_CoverPageSupplement_4_0-4.0.pdf
307998 RR_OtherProjectInfo_1_4-1.4.pdf
307998 PerformanceSite_2_0-2.0.pdf
307998 RR_KeyPersonExpanded_2_0-2.0.pdf
307998 RR_Budget_1_4-1.4.pdf
307998 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
307998 RR_SubawardBudget30_1_4-1.4.pdf
307998 PHS_AssignmentRequestForm_2_0-2.0.pdf
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