This NHLBI Prematurity and Respiratory Outcomes Program (PROP) grant is for investigating molecular mechanisms that contribute to respiratory disease risk in premature newborns. The primary purpose is to improve health outcomes within the first year of life for this vulnerable population. The program will establish up to five Clinical Research Centers (CRCs) and a Data Coordinating Center (DCC). CRCs will develop specific hypotheses regarding disease mechanisms in defined cohorts, utilizing innovative molecular and functional biomarkers to predict severity and assess risk modification. Successful proposals will demonstrate strong multidisciplinary collaboration among neonatologists, pulmonologists, and cutting-edge scientists in fields like bioengineering or molecular genetics. The grant utilizes the U01 cooperative agreement mechanism, with significant funding available for the five-year project period.
Opportunity ID: 45901
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-10-007 |
| Funding Opportunity Title: | Prematurity and Respiratory Outcomes Program (PROP) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 10, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 02, 2009 |
| Current Closing Date for Applications: | Jun 02, 2009 |
| Archive Date: | Jul 03, 2009 |
| Estimated Total Program Funding: | $18,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Heart, Lung, and Blood Institute (NHLBI) solicits grant applications from institutions/organizations to participate in a new NHLBI Prematurity and Respiratory Outcomes Program (PROP). This cooperative, multidisciplinary scientific group will investigate hypotheses on the molecular mechanisms that contribute to respiratory disease risk of the premature newborn with the long-term goal of improving outcomes in the first year of life. The Program will consist of up to five Clinical Research Centers (CRC), a Steering Committee, and a Data Coordinating Center (DCC). CRC applicants will each propose a detailed hypothesis of a mechanism that contributes to respiratory disease risk of a defined cohort, as well as innovative molecular/functional biomarkers to define the cohort, predict the severity of respiratory outcomes for that cohort, and serve as surrogate endpoints in evaluation of risk modification. This program will require collaborations between neonatologists, pulmonologists, and scientists with expertise in cutting-edge technology (such as bioengineering, molecular genetics, or imaging). Use of the multiple PI mechanism is strongly encouraged. Mechanism of Support. This FOA will utilize the Research Project Cooperative Agreement (U01) mechanism of support. Funds Available and Anticipated Number of Awards. The NHLBI intends to commit approximately $1,500,000 total costs for FY2010. The total amount to be awarded for the Prematurity and Respiratory Outcomes Program will be a maximum of $18,500,000 total costs for the 5-year project period. It is anticipated that up to 5 CRCs and 1 DCC will be awarded. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-10-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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