This grant from the National Institutes of Health (NIH) is offering funding for small, proof-of-concept clinical trials. Its primary aim is to investigate interventions with known mechanisms of action that can address chronic immune activation or persistent inflammation in individuals living with HIV. The focus is specifically on HIV-infected patients who are already on effective antiretroviral therapy. These trials must include concurrent, intensive laboratory studies. The ultimate purpose of this initiative is to pinpoint and understand specific biological mechanisms or pathways that can be effectively targeted. This knowledge will then be used to prevent or reverse persistent immune activation and inflammation, thereby improving long-term health outcomes for HIV patients.
Opportunity ID: 139093
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-12-007 |
| Funding Opportunity Title: | Targeting Inflammation and Immune Activation in HIV Disease (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 20, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jul 13, 2012 |
| Current Closing Date for Applications: | Jul 13, 2012 |
| Archive Date: | Aug 13, 2012 |
| Estimated Total Program Funding: | $2,300,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA solicits applications that propose small proof-of-concept clinical trials, with concurrent intensive laboratory studies, designed to evaluate the effect of an intervention on chronic immune activation or persistent inflammation in HIV-infected individuals who are taking effective antiretroviral therapy. The intervention must have a known mechanism of action. The goal of this initiative is to identify specific mechanisms or pathways that can be targeted to prevent or reverse persistent immune activation in HIV-infected individuals. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-12-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | ADOBE-FORMS-B2 | PKG00092610 | Jun 13, 2012 | Jul 13, 2012 | View |
Package 1
Mandatory forms
139093 RR_SF424_1_2-1.2.pdf
139093 PerformanceSite_1_4-1.4.pdf
139093 RR_OtherProjectInfo_1_3-1.3.pdf
139093 RR_KeyPersonExpanded_1_2-1.2.pdf
139093 PHS398_CoverPageSupplement_1_4-1.4.pdf
139093 PHS398_ResearchPlan_1_3-1.3.pdf
139093 PHS398_Checklist_1_3-1.3.pdf
Optional forms
139093 RR_SubawardBudget30-1.2.pdf
139093 PHS398_ModularBudget_1_2-1.2.pdf
139093 RR_Budget-1.1.pdf
139093 PHS_CoverLetter_1_2-1.2.pdf
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