The NIH Kids First Pediatric Research Program offers this grant to advance discovery of the genetic basis for childhood cancers and structural birth defects. This grant supports whole genome sequencing of pediatric cohort samples at a Kids First Program-supported center. Its purpose is to elucidate genetic contributions to childhood cancers, investigate birth defect etiology, and study molecular links between birth defects and increased cancer risk. Applicants are encouraged to sequence existing cohorts, prioritizing underrepresented racial/ethnic groups. Generated data will enrich the Kids First Data Resource Center for broad research sharing.
Opportunity ID: 345827
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-035 |
| Funding Opportunity Title: | Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 06, 2023 |
| Last Updated Date: | Feb 06, 2023 |
| Original Closing Date for Applications: | Mar 21, 2023 |
| Current Closing Date for Applications: | Mar 21, 2023 |
| Archive Date: | Apr 26, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Special district governments Small businesses State governments County governments Native American tribal governments (Federally recognized) City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer or structural birth defect cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of structural birth defects, to study the molecular basis of the associations between birth defects and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-035.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 345827 Full Announcement-PAR-23-035 -> PAR-23-035-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00279700 | Feb 20, 2023 | Mar 21, 2023 | View |
Package 1
Mandatory forms
345827 RR_SF424_5_0-5.0.pdf
345827 PHS398_CoverPageSupplement_5_0-5.0.pdf
345827 RR_OtherProjectInfo_1_4-1.4.pdf
345827 RR_KeyPersonExpanded_4_0-4.0.pdf
345827 PHS398_ResearchPlan_5_0-5.0.pdf
345827 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
345827 PHS_AssignmentRequestForm_3_0-3.0.pdf
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