The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is offering this grant to renew the Data Coordinating Center (DCC) for its Inflammatory Bowel Disease Genetics Consortium (IBDGC). Established in 2002, the IBDGC has already identified over 100 IBD susceptibility loci. This grant aims to continue the discovery of additional genetic variants and, crucially, to integrate diverse -omic methodologies (genomic, epigenomic, transcriptomic, proteomic, metabolomic) to elucidate how these genetic risk variants influence IBD pathophysiology. The selected DCC will be vital in coordinating collaboration among Genetic Research Centers, managing subject enrollment and biological sample submission, overseeing data processing and analysis, and facilitating the operations of the IBDGC’s Steering Committee, ensuring cohesive and impactful research progression.
Opportunity ID: 143255
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-11-502 |
| Funding Opportunity Title: | Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 09, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Apr 30, 2012 |
| Current Closing Date for Applications: | Apr 30, 2012 |
| Archive Date: | May 31, 2012 |
| Estimated Total Program Funding: | $1,250,000 |
| Award Ceiling: | $900,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Only institutions which have previously received an award for a DCC under RFA-DK-06-504, Announcement of a Limited Competition for the Continuation of the Inflammatory Bowel Disease Genetics Consortium (IBDGC)(U01), are eligible to submit an application in response to this FOA. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD.Since its establishment, the IBDGC, in collaboration with other international IBD genetics consortia, has identified more than 100 such susceptibility loci.However, many susceptibility genes still remain to be identified, and the work of elucidating how IBD risk-associated genetic variants influence the pathophysiology of IBD has barely begun.The purpose of this FOA is to renew the IBDGC to continue the discovery of susceptibility variants, and to integrate genomic with epigenomic, transcriptomic, proteomic, metabolomic, and other -omic methodologies to elucidate the effects of genetic risk variants on the pathophysiology of IBD.The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in accompanying RFA-DK-11-032), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and immortalization of cell lines, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees. The PD(s)/PI(s) of the DCC shall serve as a voting member of the Steering Committee of the IBDGC, and be bound by all of the operational decisions of this Committee. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-11-502.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.847 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00096812 | Mar 30, 2012 | Apr 30, 2012 | View |
Package 1
Mandatory forms
143255 RR_SF424_1_2-1.2.pdf
143255 PerformanceSite_1_4-1.4.pdf
143255 RR_OtherProjectInfo_1_3-1.3.pdf
143255 RR_KeyPersonExpanded_1_2-1.2.pdf
143255 PHS398_CoverPageSupplement_1_4-1.4.pdf
143255 PHS398_ResearchPlan_1_3-1.3.pdf
143255 PHS398_Checklist_1_3-1.3.pdf
Optional forms
143255 RR_SubawardBudget30-1.2.pdf
143255 PHS398_ModularBudget_1_2-1.2.pdf
143255 RR_Budget-1.1.pdf
143255 PHS_CoverLetter_1_2-1.2.pdf
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