The National Institute on Aging (NIA) is offering a grant for multi-site clinical validation of multimodal neuroimaging and biospecimen biomarkers. This grant’s core purpose is to enable the differential diagnosis of three or more similarly presenting neurodegenerative diseases, specifically including at least one Alzheimer’s Disease and Related Dementia (ADRD). Awarded investigators will be required to pursue the qualification of these biomarkers as therapeutic/drug development tools through the FDA’s Biomarker Qualification Program. This initiative aims to accelerate the adoption and utility of advanced diagnostic tools in clinical trials and treatment development for complex neurological conditions.
Opportunity ID: 345932
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-24-001 |
| Funding Opportunity Title: | Using Multimodal Biomarkers to Differentially Diagnose ADRDs for Clinical Trials (U19 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 09, 2023 |
| Last Updated Date: | Feb 09, 2023 |
| Original Closing Date for Applications: | Jun 01, 2023 |
| Current Closing Date for Applications: | Jun 01, 2023 |
| Archive Date: | Jul 07, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $4,700,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Independent school districts Public and State controlled institutions of higher education State governments City or township governments Small businesses For profit organizations other than small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity is to enable multi-site clinical validation of a multimodal set of neuroimaging and biospecimen biomarkers to differentially diagnosis three or more similarly presenting neurodegenerative diseases, including at least one of the Alzheimers Disease and Related Dementias (ADRDs). As part of the program deliverables, investigators will be required to work towards qualifying the candidate biomarkers as therapeutic/drug development tools through the FDAs Biomarker Qualification Program. *Note this FOA has changed Council. ICs that previously joined are already in Shared Interest. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 345932 Full Announcement-RFA-NS-24-001 -> RFA-NS-24-001-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00279816 | May 01, 2023 | Jun 01, 2023 | View |
Package 1
Mandatory forms
345932 RR_SF424_5_0-5.0.pdf
345932 PHS398_CoverPageSupplement_5_0-5.0.pdf
345932 RR_OtherProjectInfo_1_4-1.4.pdf
345932 PerformanceSite_4_0-4.0.pdf
345932 RR_KeyPersonExpanded_4_0-4.0.pdf
345932 PHS398_ResearchPlan_5_0-5.0.pdf
345932 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
345932 PHS_Additional_IndirectCosts_2_0-2.0.pdf
345932 PHS_AssignmentRequestForm_3_0-3.0.pdf
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