This DARPA grant is for the purpose of demonstrating the capability to produce recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform. The goal is for the plant-derived rBuChE to exhibit the identical pharmacokinetic profile as human plasma-derived butyrylcholinesterase (hBuChE). This funding aims to establish technical precedence for utilizing this plant platform to develop a rapid and scalable pre-exposure therapeutic bioscavenger against organophosphate nerve agents. This grant is exclusively for basic research, with an anticipated funding period of 12 months.
Opportunity ID: 144634
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-12-31 |
| Funding Opportunity Title: | Butyrylcholinesterase Expression in Plants |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Feb 16, 2012 |
| Last Updated Date: | Mar 21, 2012 |
| Original Closing Date for Applications: | Apr 26, 2012 |
| Current Closing Date for Applications: | May 17, 2012 |
| Archive Date: | Jul 17, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months. |
| Link to Additional Information: | DARPA-BAA-12-31 |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:DARPA-BAA-12-31@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Modification 2 to DARPA-BAA-12-31 is to extend the Closing Date for full proposals. See attachment DARPA-BAA-12-31 | Mar 21, 2012 | |
| Modification 1 to DARPA-BAA-12-31 is to revise DARPA’s mailing address. See attached Modification 1 for details. | Mar 21, 2012 | |
| Mar 01, 2012 |
DISPLAYING: Synopsis 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-12-31 |
| Funding Opportunity Title: | Butyrylcholinesterase Expression in Plants |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Feb 16, 2012 |
| Last Updated Date: | Mar 21, 2012 |
| Original Closing Date for Applications: | Apr 26, 2012 |
| Current Closing Date for Applications: | May 17, 2012 |
| Archive Date: | Jul 17, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months. |
| Link to Additional Information: | DARPA-BAA-12-31 |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:DARPA-BAA-12-31@darpa.mil |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-12-31 |
| Funding Opportunity Title: | Butyrylcholinesterase Expression in Plants |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Mar 21, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Apr 26, 2012 |
| Archive Date: | Jun 26, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months. |
| Link to Additional Information: | DARA-BAA-12-31 |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:DARPA-BAA-12-31@darpa.mil |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-12-31 |
| Funding Opportunity Title: | Butyrylcholinesterase Expression in Plants |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 01, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Apr 26, 2012 |
| Archive Date: | Jun 26, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months. |
| Link to Additional Information: | DARA-BAA-12-31 |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
BAA Coordinator
Email:DARPA-BAA-12-31@darpa.mil |
Related Documents
Folder 144634 Full Announcement-1 -> darpa-baa-12-31.pdf
Folder 144634 Other Supporting Documents-Modification 1 -> darpa-baa-12-31 modification 1.pdf
Folder 144634 Other Supporting Documents-Modification 2 to DARPA-BAA-12-31 1 -> darpa-baa-12-31 modification 2.pdf
Packages
| Agency Contact Information: | BAA Coordinator Email: DARPA-BAA-12-31@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00098072 | Feb 16, 2012 | May 17, 2012 | View |
Package 1
Mandatory forms
144634 RR_SF424-1.1.pdf
Optional forms
144634 RR_FedNonFedBudget-1.1.pdf
144634 RR_FedNonFed_SubawardBudget-1.2.pdf
144634 RR_OtherProjectInfo-1.1.pdf
144634 RR_Budget-1.1.pdf
144634 RR_KeyPersonExpanded-1.1.pdf
144634 RR_PerformanceSite-1.1.pdf
144634 RR_SubawardBudget-1.2.pdf
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