This grant from the National Institute of Environmental Health Sciences (NIEHS) is for establishing a Renal Science Core (RAC) to support the new Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) research consortium. The RAC will provide scientific guidance and leadership in discovery science, supporting the consortium’s analytical needs. This core will assess renal function, analyze kidney biopsies, and develop scientific approaches to understand the causes of CKDu, including planning biological sampling strategies. The CURE consortium, comprising a Data Coordinating Center, Field Sites, and the RAC, will collaborate to develop common protocols for evaluating affected individuals and controls, define strategies for biosampling and environmental assessment, and determine optimal analytic strategies. This funding specifically supports human studies and aims to enable discovery science to identify CKDu causes, disease progression, and potential public health interventions.
Opportunity ID: 328313
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-20-018 |
| Funding Opportunity Title: | Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium Renal Science Core (U01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Environment Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 24, 2020 |
| Last Updated Date: | Jul 24, 2020 |
| Original Closing Date for Applications: | Nov 10, 2020 |
| Current Closing Date for Applications: | Nov 10, 2020 |
| Archive Date: | Dec 16, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications for a Renal Science Core to support and provide scientific guidance as part of the new consortium to study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The Renal Analytic Core (RAC) will provide leadership in discovery science and support the analytic needs of the new consortium. The RAC will assess renal function, analyze kidney biopsies, devise and carry out a scientific approach to understanding the cause or causes of CKDu, including planning a biological sampling strategy to be implemented at Field Sites. This collaborative research consortium will bring together a broad range of expertise and enable discovery science to understand the cause or causes of CKDu and disease progression. The consortium will also work to identify potential therapeutic targets and public health interventions. The consortium will consist of a Scientific Data Coordinating Center, Field Sites, a Renal Analytic Core and the NIEHS Human Health Exposure Analysis Resource (HHEAR). The consortium will work together to develop common protocols for evaluation of participants who are currently affected with early manifestations of CKDu and control participants, to define common strategies for biosampling and environmental assessment, and to determine analytic strategies to best use the samples collected by the consortium. This FOA will not support intervention trials to prevent or treat CKDu. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-018.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262738 | Oct 10, 2020 | Nov 10, 2020 | View |
Package 1
Mandatory forms
328313 RR_SF424_2_0-2.0.pdf
328313 PHS398_CoverPageSupplement_5_0-5.0.pdf
328313 RR_OtherProjectInfo_1_4-1.4.pdf
328313 PerformanceSite_2_0-2.0.pdf
328313 RR_KeyPersonExpanded_2_0-2.0.pdf
328313 PHS398_ResearchPlan_4_0-4.0.pdf
328313 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328313 RR_Budget_1_4-1.4.pdf
328313 RR_SubawardBudget30_1_4-1.4.pdf
328313 PHS398_ModularBudget_1_2-1.2.pdf
328313 PHS_AssignmentRequestForm_3_0-3.0.pdf
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