This grant is for understanding the profound impact of sex differences on Alzheimer’s Disease (AD) and AD-related dementia (ADRD). It invites applications employing a rigorous cross-disciplinary and team science approach to comprehensively explore the mechanistic underpinnings of how sex differences influence brain aging trajectories, diverse disease phenotypes, and the overall risk of developing AD/ADRD. Furthermore, the initiative aims to advance precision medicine strategies for effective AD/ADRD treatment and prevention. This includes investigating responsiveness to both pharmacologic and non-pharmacologic interventions, ensuring a nuanced understanding of sex-specific factors to improve therapeutic outcomes and develop tailored approaches for patients.
Opportunity ID: 328378
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-21-029 |
| Funding Opportunity Title: | Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 27, 2020 |
| Last Updated Date: | Jul 27, 2020 |
| Original Closing Date for Applications: | Nov 10, 2020 |
| Current Closing Date for Applications: | Nov 10, 2020 |
| Archive Date: | Dec 16, 2020 |
| Estimated Total Program Funding: | $5,500,000 |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Small businesses Private institutions of higher education Independent school districts Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications that apply a cross-disciplinary and team science approach to gain comprehensive mechanistic understanding of the impact of sex differences on the trajectories of brain aging, phenotypes, and risk of Alzheimer’s Disease (AD) and AD-related dementia (ADRD), and on precision medicine for treatment and prevention of AD/ADRD, including the responsiveness to pharmacologic and non-pharmacologic interventions. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-21-029.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262804 | Oct 10, 2020 | Nov 10, 2020 | View |
Package 1
Mandatory forms
328378 RR_SF424_2_0-2.0.pdf
328378 PHS398_CoverPageSupplement_5_0-5.0.pdf
328378 RR_OtherProjectInfo_1_4-1.4.pdf
328378 PerformanceSite_2_0-2.0.pdf
328378 RR_KeyPersonExpanded_2_0-2.0.pdf
328378 PHS398_ResearchPlan_4_0-4.0.pdf
328378 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328378 RR_Budget_1_4-1.4.pdf
328378 RR_SubawardBudget30_1_4-1.4.pdf
328378 PHS398_ModularBudget_1_2-1.2.pdf
328378 PHS_AssignmentRequestForm_3_0-3.0.pdf
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