This grant, offered by the National Institutes of Health (NIH), invites research proposals focused on unraveling the intricate mechanisms by which abnormal proteins disseminate throughout the nervous systems of individuals afflicted with Frontotemporal Dementia (FTD) and Lewy Body Dementia (LBD). The primary purpose is to advance our understanding of how these pathological proteins spread, contributing to disease progression. Priority will be given to applications that extend beyond single-mechanism investigations, instead exploring the complexities of spread within the context of multiple proteinopathies, diverse cell and circuit types, and various neurological pathways. This funding opportunity aims to foster comprehensive studies into the fundamental processes driving neurodegenerative pathology in these conditions.
Opportunity ID: 328564
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-21-006 |
| Funding Opportunity Title: | Mechanisms of Pathological Spread of Abnormal Proteins in LBD and FTD (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2020 |
| Last Updated Date: | Aug 06, 2020 |
| Original Closing Date for Applications: | Oct 27, 2020 |
| Current Closing Date for Applications: | Oct 27, 2020 |
| Archive Date: | Dec 02, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses State governments Independent school districts For profit organizations other than small businesses Native American tribal governments (Federally recognized) City or township governments County governments Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement invites research on the mechanism(s) by which abnormal proteins spread throughout the nervous systems of patients with Frontotemporal Dementia and/or Lewy Body Dementia. Applications that move beyond a focus on one mechanisms of spread to consider how spreading might proceed in the context of multiple proteinopathies, multiple cell/circuit types, and multiple pathways are of particular interest. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262900 | Sep 27, 2020 | Oct 27, 2020 | View |
Package 1
Mandatory forms
328564 RR_SF424_2_0-2.0.pdf
328564 PHS398_CoverPageSupplement_5_0-5.0.pdf
328564 RR_OtherProjectInfo_1_4-1.4.pdf
328564 PerformanceSite_2_0-2.0.pdf
328564 RR_KeyPersonExpanded_2_0-2.0.pdf
328564 PHS398_ResearchPlan_4_0-4.0.pdf
328564 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328564 RR_Budget_1_4-1.4.pdf
328564 RR_SubawardBudget30_1_4-1.4.pdf
328564 PHS398_ModularBudget_1_2-1.2.pdf
328564 PHS_AssignmentRequestForm_3_0-3.0.pdf
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