This grant is for advancing our understanding of neurodegenerative diseases, specifically Lewy Body Dementia (LBD) and Frontotemporal Dementia (FTD). These conditions are characterized by the accumulation of abnormal proteins like alpha-synuclein or tau in specific brain regions, leading to distinct clinical presentations. The purpose of this funding opportunity is to support innovative research applications focused on identifying the underlying mechanisms responsible for this selective regional vulnerability to abnormal protein deposition. By uncovering why certain brain structures, cells, or circuits are more susceptible in LBD and FTD, researchers can significantly contribute to developing new diagnostic tools and targeted therapeutic interventions aimed at mitigating disease progression.
Opportunity ID: 328666
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-21-007 |
| Funding Opportunity Title: | Mechanisms of Selective Vulnerability in LBD and FTD (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 13, 2020 |
| Last Updated Date: | Aug 13, 2020 |
| Original Closing Date for Applications: | Oct 27, 2020 |
| Current Closing Date for Applications: | Oct 27, 2020 |
| Archive Date: | Dec 02, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Public and State controlled institutions of higher education City or township governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Accumulation of abnormal proteins such as alpha-synuclein or tau in the brains of patients with dementia tends to occur in specific brain structures (cells/circuits/regions), resulting in the unique clinical presentations that are characteristic of the different types of dementia. This funding opportunity announcement invites applications that seek to identify mechanisms responsible for this selective regional vulnerability to abnormal protein deposition in the brains of patients with Lewy Body Dementia or Frontotemporal Dementia. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262996 | Sep 27, 2020 | Oct 27, 2020 | View |
Package 1
Mandatory forms
328666 RR_SF424_2_0-2.0.pdf
328666 PHS398_CoverPageSupplement_5_0-5.0.pdf
328666 RR_OtherProjectInfo_1_4-1.4.pdf
328666 PerformanceSite_2_0-2.0.pdf
328666 RR_KeyPersonExpanded_2_0-2.0.pdf
328666 PHS398_ResearchPlan_4_0-4.0.pdf
328666 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328666 RR_Budget_1_4-1.4.pdf
328666 RR_SubawardBudget30_1_4-1.4.pdf
328666 PHS398_ModularBudget_1_2-1.2.pdf
328666 PHS_AssignmentRequestForm_3_0-3.0.pdf
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