This grant, offered by the National Institutes of Health (NIH), is specifically designed to support innovative basket clinical trials. The primary purpose is to advance research into drugs that target shared molecular etiologies across more than one rare disease. This funding opportunity aims to streamline the drug development process by testing the efficacy of a single drug against a common underlying mechanism, even if it manifests in different rare conditions. Researchers are encouraged to propose trials that identify and leverage these shared biological pathways, offering a more efficient and targeted approach to developing treatments for a broader spectrum of rare diseases, ultimately accelerating therapeutic breakthroughs for underserved patient populations.
Opportunity ID: 329061
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-20-031 |
| Funding Opportunity Title: | Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (UG3/UH3 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 15, 2020 |
| Last Updated Date: | Sep 15, 2020 |
| Original Closing Date for Applications: | Nov 12, 2020 |
| Current Closing Date for Applications: | Nov 12, 2020 |
| Archive Date: | Dec 18, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Special district governments Small businesses City or township governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support basket clinical trials of drugs targeting shared molecular etiologies in more than one rare disease. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-20-031.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00263415 | Oct 12, 2020 | Nov 12, 2020 | View |
Package 1
Mandatory forms
329061 RR_SF424_2_0-2.0.pdf
329061 PHS398_CoverPageSupplement_5_0-5.0.pdf
329061 RR_OtherProjectInfo_1_4-1.4.pdf
329061 PerformanceSite_2_0-2.0.pdf
329061 RR_KeyPersonExpanded_2_0-2.0.pdf
329061 RR_Budget_1_4-1.4.pdf
329061 PHS398_ResearchPlan_4_0-4.0.pdf
329061 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
329061 RR_SubawardBudget30_1_4-1.4.pdf
329061 PHS_AssignmentRequestForm_3_0-3.0.pdf
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