The National Institute on Aging (NIA) is offering this grant to support the development and rigorous validation of clinically relevant models for Alzheimer’s Disease and Related Dementias (ADRD), including post-TBI dementias. This grant is for the purpose of advancing novel research tools, which may include small and large animal models, ex vivo systems, human iPSCs, or other in vitro approaches. Validation encompasses internal, face, construct, and predictive methods, examining underlying mechanisms, functional imaging, behavior, and cognitive readouts. The ultimate goal is to facilitate therapy development or deepen understanding of human disease mechanisms and neurodegenerative predisposition. Models must accurately reflect human conditions, with emphasis on innovative approaches addressing gaps, especially for complex pathologies and comorbidities.
Opportunity ID: 347436
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-23-154 |
| Funding Opportunity Title: | Development and Validation of Models for Alzheimers Disease-Related Dementias (ADRD) (R61/R33 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 11, 2023 |
| Last Updated Date: | Apr 11, 2023 |
| Original Closing Date for Applications: | Oct 20, 2023 |
| Current Closing Date for Applications: | Oct 20, 2023 |
| Archive Date: | Nov 25, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $360,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Private institutions of higher education State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | “This FOA would support development and validation of clinically relevant models of AD/ADRD including post-TBI dementias. Models could include small animals, larger animals, ex vivo models, human iPSCs, or other in vitro models. Validation includes internal, face, construct, and predictive (to the extent possible) validation. Such validations could include looking at underlying mechanism/pathways, functional imaging, behavior, and other cognitive readouts. Independent replication is also encouraged. These models can be developed/validated with the goal of supporting therapy development or better understanding of human disease mechanisms and mechanisms that uncover predisposition to developing neurodegenerative dementias. Either way, it is essential that models reflect the human condition as much as possible. Novel models of complex pathology or comorbid conditions are encouraged. Such models could include multiple manipulations (genetics, environment, lifestyle, age, etc.) to better reflect the complex interaction of risk factors in patients. New models need to be innovative and address a gap in the currently available models.” |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-23-154.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 347436 Full Announcement-PAR-23-154 -> PAR-23-154-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00281097 | May 20, 2023 | Oct 20, 2023 | View |
Package 1
Mandatory forms
347436 RR_SF424_5_0-5.0.pdf
347436 PHS398_CoverPageSupplement_5_0-5.0.pdf
347436 RR_OtherProjectInfo_1_4-1.4.pdf
347436 PerformanceSite_4_0-4.0.pdf
347436 RR_KeyPersonExpanded_4_0-4.0.pdf
347436 RR_Budget_3_0-3.0.pdf
347436 PHS398_ResearchPlan_5_0-5.0.pdf
347436 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
347436 RR_SubawardBudget30_3_0-3.0.pdf
347436 PHS_AssignmentRequestForm_3_0-3.0.pdf
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