This Funding Opportunity Announcement from various NIH Institutes (NIMH, NEI, NIAAA, NIDA, NIA, NIDCD) offers a grant to support investigators in discovering in vivo chemical probes for novel brain targets. This grant is specifically for researchers with validated starting compounds (hits) and bioassays for testing new analogs. The primary purpose is to stimulate research in developing novel small molecules to understand biological processes relevant to the missions of these institutes and to discover or validate new biological targets informing brain disease mechanisms. Emphasis is placed on projects yielding new insights into critical disease-related biological targets and processes, with the main focus on the discovery of in vivo chemical probes for the nervous system.
Opportunity ID: 329438
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-029 |
| Funding Opportunity Title: | Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 15, 2020 |
| Last Updated Date: | Oct 15, 2020 |
| Original Closing Date for Applications: | Jan 07, 2024 |
| Current Closing Date for Applications: | Jan 07, 2024 |
| Archive Date: | Feb 12, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Special district governments County governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have in hand the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds. Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of NIMH, NEI, NIAAA, NIDA, NIA and/or NIDCD and 2) discovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes. The main emphasis of projects submitted under this FOA should be in the discovery of in vivo chemical probes. Applicants interested in developing cell-based chemical probes may wish to apply using the companion R21 mechanism TEMP-8443. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-029.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 329438 Full Announcement-PAR-21-029 -> PAR-21-029-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00263781 | Jan 05, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00269785 | Oct 28, 2021 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277724 | Nov 01, 2022 | Jan 07, 2024 | View |
Package 1
Mandatory forms
329438 RR_SF424_2_0-2.0.pdf
329438 PHS398_CoverPageSupplement_5_0-5.0.pdf
329438 RR_OtherProjectInfo_1_4-1.4.pdf
329438 PerformanceSite_2_0-2.0.pdf
329438 RR_KeyPersonExpanded_2_0-2.0.pdf
329438 PHS398_ResearchPlan_4_0-4.0.pdf
329438 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
329438 RR_Budget_1_4-1.4.pdf
329438 RR_SubawardBudget30_1_4-1.4.pdf
329438 PHS398_ModularBudget_1_2-1.2.pdf
329438 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
329438 RR_SF424_5_0-5.0.pdf
329438 PHS398_CoverPageSupplement_5_0-5.0.pdf
329438 RR_OtherProjectInfo_1_4-1.4.pdf
329438 PerformanceSite_4_0-4.0.pdf
329438 RR_KeyPersonExpanded_4_0-4.0.pdf
329438 PHS398_ResearchPlan_4_0-4.0.pdf
329438 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329438 RR_Budget_3_0-3.0.pdf
329438 RR_SubawardBudget30_3_0-3.0.pdf
329438 PHS398_ModularBudget_1_2-1.2.pdf
329438 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
329438 RR_SF424_5_0-5.0.pdf
329438 PHS398_CoverPageSupplement_5_0-5.0.pdf
329438 RR_OtherProjectInfo_1_4-1.4.pdf
329438 PerformanceSite_4_0-4.0.pdf
329438 RR_KeyPersonExpanded_4_0-4.0.pdf
329438 PHS398_ResearchPlan_5_0-5.0.pdf
329438 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329438 RR_Budget_3_0-3.0.pdf
329438 RR_SubawardBudget30_3_0-3.0.pdf
329438 PHS398_ModularBudget_1_2-1.2.pdf
329438 PHS_AssignmentRequestForm_3_0-3.0.pdf
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