This grant from the National Heart, Lung, and Blood Institute (NHLBI) is for comparing the effectiveness of two distinct data sources—electronic health records (EHR) and traditional prospective patient-based clinical data—in studying outcomes related to pediatric pulmonary vascular disease (PVD). The aim is to answer critical research questions regarding the natural history, long-term outcomes, and therapeutic responses for this rare and heterogeneous condition in children. Applicants are expected to propose methods for developing these data sources, identify at least three pertinent pediatric PVD research questions, and outline a comparison method to assess the utility of each data approach. This work seeks to elucidate EHR value for clinical management and optimize future clinical trial designs to improve health outcomes for children with PVD.
Opportunity ID: 173853
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-14-005 |
| Funding Opportunity Title: | Comparison of Strategies to Study Pediatric Pulmonary Vascular Disease Outcomes Using Bioinformatics (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 01, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Feb 21, 2013 |
| Current Closing Date for Applications: | Feb 21, 2013 |
| Archive Date: | Mar 24, 2013 |
| Estimated Total Program Funding: | $1,800,000 |
| Award Ceiling: | $1,800,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Independent school districts County governments State governments Public housing authorities/Indian housing authorities Private institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Under this Funding Opportunity Announcement (FOA), the National Heart, Lung, and Blood Institute (NHLBI) invites applications to support a comparison of the ability of two data sources, electronic health records and traditional prospective patient-based clinical and research data, to answer research questions regarding the natural history, longitudinal outcomes, and phenotypes of therapeutic response for pediatric pulmonary vascular disease (PVD).There will be one award for a Bioinformatics Clinical Coordinating Center (BCCC).Because PVD in children is rare and heterogeneous, the applicant will develop, implement, and evaluate the strengths and limitations of two data collection approaches to answer research questions regarding the natural history, longitudinal outcomes, and phenotypes of therapeutic response.The prospective data collection strategies proposed should include utilizing: 1) electronic health records (EHR) and 2) traditional prospective patient-based clinical and research data.Applicants should propose: 1) methods, plans, and expertise required to develop the two data sources; 2) at least three research pediatric PVD questions that the data collection strategies can address; and 3) a method to compare the usefulness of the two data sources to answer the research questions. This work will elucidate the value of EHR in answering real-world clinical management questions with the ultimate goal of improving health outcomes for children treated for PVD, and optimizing clinical trial design.The work will require multidisciplinary and multi-institutional team coordination that includes expertise in bioinformatics and computational science and clinical knowledge and access to pediatric patients with PVD. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-14-005.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.838 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00124650 | Jan 21, 2013 | Feb 21, 2013 | View |
Package 1
Mandatory forms
173853 RR_SF424_1_2-1.2.pdf
173853 PerformanceSite_1_4-1.4.pdf
173853 RR_OtherProjectInfo_1_3-1.3.pdf
173853 RR_KeyPersonExpanded_1_2-1.2.pdf
173853 PHS398_CoverPageSupplement_1_4-1.4.pdf
173853 PHS398_ResearchPlan_1_3-1.3.pdf
173853 PHS398_Checklist_1_3-1.3.pdf
Optional forms
173853 RR_SubawardBudget30-1.2.pdf
173853 PHS398_ModularBudget_1_2-1.2.pdf
173853 RR_Budget-1.1.pdf
173853 PHS_CoverLetter_1_2-1.2.pdf
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