This BRAIN Initiative grant, reissued by the National Institute of Mental Health (NIMH), is for developing and validating innovative tools to analyze and manipulate complex brain circuits, aiming to understand cellular interactions underpinning brain function. Critical advances in treating human brain disorders are hindered by limited safe, minimally invasive methods to monitor and manipulate neural circuitry. While many neuroscience tools exist, most are tailored for smaller model organisms. This initiative specifically addresses the pressing need for cutting-edge tools adaptable for larger brains, directly relevant to humans, and potentially translatable into therapeutic strategies. Proposals must focus on tools exploiting cell-type or circuit-level specificity, with robust validation plans essential for successful applications. The grant seeks to overcome barriers to gene therapy delivery and precise targeting of dysfunctional brain areas.
Opportunity ID: 348003
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-23-295 |
| Funding Opportunity Title: | BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 08, 2023 |
| Last Updated Date: | May 08, 2023 |
| Original Closing Date for Applications: | Jun 07, 2024 |
| Current Closing Date for Applications: | Jun 07, 2024 |
| Archive Date: | Jul 13, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities State governments Public and State controlled institutions of higher education Private institutions of higher education Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-23-295.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 348003 Full Announcement-RFA-MH-23-295 -> RFA-MH-23-295-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00281561 | May 08, 2023 | Jun 07, 2024 | View |
Package 1
Mandatory forms
348003 RR_SF424_5_0-5.0.pdf
348003 PHS398_CoverPageSupplement_5_0-5.0.pdf
348003 RR_OtherProjectInfo_1_4-1.4.pdf
348003 PerformanceSite_4_0-4.0.pdf
348003 RR_KeyPersonExpanded_4_0-4.0.pdf
348003 RR_Budget_3_0-3.0.pdf
348003 PHS398_ResearchPlan_5_0-5.0.pdf
348003 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
348003 RR_SubawardBudget30_3_0-3.0.pdf
348003 PHS_AssignmentRequestForm_3_0-3.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
