The National Institute on Aging (NIA) is offering this grant to support early-phase (Phase 1, 2a, and 2b) clinical trials. This grant is for investigating novel or re-purposed interventions, including new compounds, existing drugs, biologics (excluding stem cells), or supplements. The primary purpose is to identify and test substances that can prevent, delay, or treat multiple chronic conditions by targeting fundamental aging-related mechanisms. Additionally, it aims to evaluate compounds that affect specific diseases and conditions disproportionately impacting older adults. Please note, this funding opportunity is not intended to support definitive efficacy and safety trials, but rather initial exploratory clinical development.
Opportunity ID: 331296
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-22-011 |
| Funding Opportunity Title: | Early-Phase Clinical Trials of Novel Interventions to Prevent, Delay, or Treat Aging-Related Conditions by Targeting Aging-Related Mechanisms (U01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 03, 2021 |
| Last Updated Date: | Feb 03, 2021 |
| Original Closing Date for Applications: | Jun 17, 2021 |
| Current Closing Date for Applications: | Jun 17, 2021 |
| Archive Date: | Jul 23, 2021 |
| Estimated Total Program Funding: | $4,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments County governments Private institutions of higher education Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | NIA invites applications for Phase 1, 2a, and 2b clinical trials of new compounds or re-purposed existing drugs, biologics (except stem cells), or supplements to treat multiple chronic conditions by modulating fundamental aging-related mechanisms as well as to test compounds that could affect the individual diseases and conditions disproportionally affecting older adults. This FOA is not intended to provide support for definitive efficacy and safety trials. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-22-011.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00265292 | May 17, 2021 | Jun 17, 2021 | View |
Package 1
Mandatory forms
331296 RR_SF424_2_0-2.0.pdf
331296 PHS398_CoverPageSupplement_5_0-5.0.pdf
331296 RR_OtherProjectInfo_1_4-1.4.pdf
331296 PerformanceSite_2_0-2.0.pdf
331296 RR_KeyPersonExpanded_2_0-2.0.pdf
331296 PHS398_ResearchPlan_4_0-4.0.pdf
331296 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
331296 RR_Budget_1_4-1.4.pdf
331296 RR_SubawardBudget30_1_4-1.4.pdf
331296 PHS398_ModularBudget_1_2-1.2.pdf
331296 PHS_AssignmentRequestForm_3_0-3.0.pdf
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