The Library of Integrated Network-Based Cellular Signatures (LINCS) program is offering this grant to establish pilot-scale data production for identifying mechanism-based associations among biological perturbations. This grant is for supporting high-throughput collection and integrative computational analysis of molecular activity and cellular feature signatures induced by perturbing agents in selected cell types. The resulting knowledge will form a long-lived resource, informing disease states, gene networks, and drug mechanisms. This funding opportunity seeks proposals addressing method optimization, data integration, and scalability to produce an initial, usable resource, complementing future LINCS components. Up to two U54 cooperative agreement awards are anticipated, with significant funding available over three years.
Opportunity ID: 52215
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-10-003 |
| Funding Opportunity Title: | Large Scale Production of Perturbagen-Induced Cellular Signatures (U54) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 26, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Apr 27, 2010 |
| Current Closing Date for Applications: | Apr 27, 2010 |
| Archive Date: | May 28, 2010 |
| Estimated Total Program Funding: | $12,700,000 |
| Award Ceiling: | $900,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Independent school districts Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA seeks to establish a pilot-scale data production effort to systematize approaches for identifying mechanism-based associations among the effects of disparate biological perturbations, a knowledge base that can be used to study functional relationships among the responding cellular components. The Library of Integrated Network-Based Cellular Signatures (LINCS) program will support the high-throughput collection and integrative computational analysis of informative molecular activity and cellular feature signatures generated in response to a variety of perturbing agents, including siRNAs and small bioactive molecules, which are applied to a set of carefully selected cell types. The resulting knowledge will form the basis of a long-lived resource that can be used broadly by the community. For example LINCS may inform association of disease states with detailed molecular or cellular phenotypes, and ultimately associate disease with specific gene networks, or inform the mechanism of action of known drugs. This FOA seeks to fund pilot-scale data production efforts that will produce a usable initial resource while addressing the following issues: optimization of methods, integration of data, and scalability. Pilot production efforts will interact with multiple future additional components (data analysis and informatics tools; and development and integration of new production-ready technologies) of the LINCS program. Mechanism of Support. This FOA will utilize the U54 specialized centers cooperative agreement award mechanism. It is intended to complement FOAs that will be issued in FY 2011 for development and integration of new production-ready technologies and for development of informatics and data analysis tools for LINCS. Funds Available and Anticipated Number of Awards. We expect to fund up to two awards in FY 2010. Three years of funding may be requested. Total funds available for the program are $2.7M in FY 2010, ramping to $5M in each of FY 2011 and FY 2012. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-10-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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