This Department of Defense (DoD) grant is dedicated to establishing a comprehensive understanding of the chronic effects of neurotrauma, primarily focusing on mild Traumatic Brain Injury (mTBI)/concussion. Recent research indicates TBI can lead to neuronal changes and lasting impairments, with chronic consequences in some individuals. The grant addresses three critical issues: identifying mechanisms, evaluating how comorbidities are associated with neurotrauma, and developing appropriate treatment and rehabilitative strategies. A key priority is advancing diagnostics, including biomarkers, and novel therapeutic approaches to improve the long-term health of Service Members and Veterans. The Consortium will coordinate translational preclinical and clinical studies, emphasizing basic research on mechanisms and clinical studies on comorbidities, with a progression toward translational/clinical work over time.
Opportunity ID: 198473
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-12-PHTBI-CENC |
| Funding Opportunity Title: | DoD Psychological Health and Traumatic Brain Injury Chronic Effects of Neurotrauma Consortium Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 06, 2012 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 04, 2013 |
| Current Closing Date for Applications: | Jan 04, 2013 |
| Archive Date: | Feb 03, 2013 |
| Estimated Total Program Funding: | $37,175,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | Recent research has indicated that TBI, including mild TBI (mTBI)/concussion with repeated exposures, leads to neuronal changes, and cognitive, behavioral, psychological, and sensory impairments. Further, research suggests that TBI, including mTBI, leads to chronic consequences (lasting 3 months or greater) in some individuals having experienced a TBI. Three critical issues related to the chronic effects of neurotrauma (over the lifespan of the patient) remain:(1) identification and characterization of the anatomic, molecular, and physiological mechanisms;(2) evaluation of how comorbidities are associated with and exacerbated by neurotrauma; and(3) appropriate treatment and rehabilitative strategies. This Consortium effort will be dedicated to establishing a comprehensive understanding of the chronic sequelae associated with neurotrauma, primarily focused on mTBI/concussion as defined by the DoD/VA. Briefly, the DoD/VA defines mTBI as associated with normal structural imaging (excluding DTI, fMRI, etc.), loss of consciousness lasting 30 minutes or less, alteration of consciousness/mental state from a moment up to 24 hours, and post-traumatic amnesia lasting 1 day or less. (The full DoD/VA mTBI definition is provided in the General Application Instructions, Appendix 7.) A key priority of this Consortium is the development of diagnostics, including a broad range of biomarkers, and novel treatment and rehabilitative strategies to improve the long-term health and well-being of Service Members and Veterans. The Consortium will coordinate research activities, including translational preclinical and clinical studies, as well as the collection, storage, use, and analyses of data and anatomical specimens, with an emphasis on basic and preclinical studies to address the anatomic, molecular, and physiological mechanisms issues and a heavy emphasis on clinical studies to address the comorbidities issues. There must be an emphasis on and progression toward translational/clinical work over the course of the Consortium. In the case of studies involving animal models, justification of validation is required at the time of application submission. Introduction of any new animal models will require clear justification. For applications studying blast-related TBI, teams should have access to an expert in the study of blast physics. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
301-682-5507
Email:help@cdmrp.org |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 198473 Full Announcement-1 -> fy12 phtbi cenc pa_final v2.pdf
Folder 198473 Revised Full Announcement-1 -> fy12 phtbi cenc pa_final v3.pdf
Folder 198473 Revised Full Announcement-2 -> phtbirp_fy12 cenc pa_gg3.pdf
Packages
| Agency Contact Information: | 301-682-5507 Email: help@cdmrp.org |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00143430 | Sep 06, 2012 | Jan 04, 2013 | View |
Package 1
Mandatory forms
198473 RR_SF424_1_2-1.2.pdf
198473 PerformanceSite_1_4-1.4.pdf
198473 RR_Budget-1.1.pdf
198473 RR_KeyPersonExpanded_1_2-1.2.pdf
Optional forms
198473 RR_SubawardBudget30-1.2.pdf
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