This grant, offered by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH), is for evaluating the pharmacokinetics (PK) of anti-tuberculosis (anti-TB) drugs and their interactions with anti-HIV medications in children with HIV/TB co-infection. Pediatric research in this crucial area significantly lags behind adult studies. The R01 funding aims to define appropriate anti-TB dosing, optimize the management of TB/HIV co-infection in children, and generate vital knowledge regarding central nervous system (CNS) penetration of anti-TB agents in the context of antiretroviral therapy. This will provide preliminary data on how PK parameters affect treatment outcomes, addressing an urgent need to improve care for co-infected pediatric patients.
Opportunity ID: 52453
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HD-09-015 |
| Funding Opportunity Title: | Pharmacokinetic Research in Pediatric HIV/TB Co-Infection (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 04, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Aug 24, 2010 |
| Current Closing Date for Applications: | Aug 24, 2010 |
| Archive Date: | Sep 24, 2010 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Small businesses City or township governments County governments Private institutions of higher education Native American tribal governments (Federally recognized) State governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This Funding Opportunity Announcement (FOA), issued by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH), encourages Research Project Grant (R01) applications from institutions/organizations that propose to evaluate the pharmacokinetics of anti-tuberculosis (anti-TB) drugs and pharmacokinetic drug interactions between anti-TB drugs and anti-HIV medications, and to potentially provide preliminary data regarding the effect of such pharmacokinetic parameters on the outcome of treatment in children with HIV/TB co-infection.Pediatric research in these areas lags far behind that in adults due to the many challenges surrounding the diagnosis and management of TB disease in children. Research related to the treatment of TB in the context of pediatric HIV/TB co-infection is urgently needed.This FOA will support grants to define appropriate dosing of anti-TB agents in HIV-infected children and that will generate knowledge regarding the optimization of management of TB/HIV co-infection in children, including the management of central nervous system (CNS) involvement with TB through the evaluation of CNS penetration of anti-TB agents in the context of antiretroviral therapy.
Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism and is issued in parallel with an FOA of identical scientific scope, RFA HD-09-016 that solicits applications under the R21 grant mechanism. Funds Available and Anticipated Number of Awards. The NICHD intends to commit $1.15 million (total costs), and NIMH intends to commit $350,000 (total costs) in FY 2010 to support one to three meritorious applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-09-015.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00016906 | Jul 24, 2010 | Aug 24, 2010 | View |
Package 1
Mandatory forms
52453 RR_SF424_1_2-1.2.pdf
52453 PerformanceSite_1_3-1.3.pdf
52453 RR_OtherProjectInfo_1_2-1.2.pdf
52453 RR_KeyPersonExpanded_1_2-1.2.pdf
52453 PHS398_CoverPageSupplement_1_4-1.4.pdf
52453 PHS398_ResearchPlan_1_3-1.3.pdf
52453 PHS398_Checklist_1_3-1.3.pdf
Optional forms
52453 PHS_CoverLetter_1_2-1.2.pdf
52453 PHS398_ModularBudget-1.1.pdf
52453 RR_Budget-1.1.pdf
52453 RR_SubawardBudget-1.2.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
