This National Heart, Lung, and Blood Institute (NHLBI) grant is for establishing Lung Transplant Clinical Centers (CCs) to form a cooperative, multi-site Lung Transplant Consortium (LTC). The consortium aims to support CCs in conducting observational and mechanistic clinical research studies. The primary goal is to understand how specific lung transplant selection and management strategies influence donor lung utilization and early post-transplant outcomes, such as primary graft dysfunction (PGD) and acute lung allograft dysfunction (ALAD). Applicants must comprise multidisciplinary teams with a combined annual lung transplant volume of at least 100. Funded centers will propose hypothesis-driven questions, collect observational data and biospecimens, enroll participants, and contribute to a core shared dataset. This collaborative effort leverages longitudinal resources to advance lung transplantation research.
Opportunity ID: 331745
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-22-002 |
| Funding Opportunity Title: | Lung Transplant Consortium – Clinical Centers (U01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 25, 2021 |
| Last Updated Date: | Feb 25, 2021 |
| Original Closing Date for Applications: | Jun 15, 2021 |
| Current Closing Date for Applications: | Jun 15, 2021 |
| Archive Date: | Jul 21, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $275,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education County governments Private institutions of higher education State governments Native American tribal governments (Federally recognized) Special district governments Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) seeks applications from lung transplant clinical centers (CCs) to form a cooperative multi-site Lung Transplant Consortium (LTC). The LTC will support CCs in conducting observational and complementary mechanistic clinical research studies that aim to understand the impact of site-specific lung transplant selection criteria and clinical management strategies on donor lung utilization and/or early post-transplant outcomes such as the development of primary graft dysfunction (PGD) and acute lung allograft dysfunction (ALAD) in recipients. Each CC application must consist of a multidisciplinary investigative team that includes a lung transplant surgeon and a lung transplant pulmonologist, and be comprised of primary and subsites that have a combined annual lung transplant volume of at least 100 transplants. Each CC application should propose hypothesis-driven scientific questions to assess certain donor and/or recipient clinical practices and their impact on donor lung utilization, PGD, ALAD or other relevant short-term outcomes that can be addressed through observational data and/or biospecimen collection and analysis at the sites included in their application. In addition, the CCs will be expected to enroll participants and contribute to a core set of data and biospecimens to be collected across all participating consortium sites through the implementation of a common research protocol under the auspices of a centralized Data Coordinating Center (DCC) and a Steering Committee (SC). By leveraging this shared longitudinal resource, LTC investigators will have the tools to identify and answer additional important research questions involving lung transplantation. This FOA runs in parallel with a separate FOA that invites applications for the LTC Data Coordinating Center, solicited under RFA-HL-22-003. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-22-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00265686 | May 15, 2021 | Jun 15, 2021 | View |
Package 1
Mandatory forms
331745 RR_SF424_2_0-2.0.pdf
331745 PHS398_CoverPageSupplement_5_0-5.0.pdf
331745 RR_OtherProjectInfo_1_4-1.4.pdf
331745 PerformanceSite_2_0-2.0.pdf
331745 RR_KeyPersonExpanded_2_0-2.0.pdf
331745 PHS398_ResearchPlan_4_0-4.0.pdf
331745 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
331745 RR_Budget_1_4-1.4.pdf
331745 RR_SubawardBudget30_1_4-1.4.pdf
331745 PHS398_ModularBudget_1_2-1.2.pdf
331745 PHS_AssignmentRequestForm_3_0-3.0.pdf
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