The National Heart, Lung, and Blood Institute (NHLBI) offers this U01 cooperative agreement grant to investigate the functional impact of human genetic variation. This grant aims to add a functional dimension to genomic studies by integrating cellular reprogramming, molecular profiling, and genomics. The purpose is to understand how naturally occurring human genetic variation influences biological networks in cell-based disease models. The program supports phased technology development, including generating and differentiating induced pluripotent stem cells (iPS) from human samples, scaling for high-throughput studies, and testing genome-wide association study (GWAS) functional hypotheses in cell models.
Opportunity ID: 52793
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-11-006 |
| Funding Opportunity Title: | Next Generation Genetic Association Studies (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.837 — Cardiovascular Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 15, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 15, 2010 |
| Current Closing Date for Applications: | Jun 15, 2010 |
| Archive Date: | Jul 16, 2010 |
| Estimated Total Program Funding: | $76,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Public housing authorities/Indian housing authorities Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses City or township governments County governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA issued by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, encourages applications from institutions or organizations that propose to utilize cellular reprogramming, molecular profiling, and genomics to investigate functional aspects of genetic variation in humans. NHLBI is soliciting a phased technology development and implementation program whose goal is to add a functional dimension to genomic studies by combining cellular reprogramming strategies with molecular profiling or cellular assays, followed by integration of this information with existing genotypic and clinical phenotypic data to assess how naturally occurring human genetic variation influences the activities of biological networks in cell-based models of disease. Since the design and conduct of such studies will require several areas of expertise, applicants are encouraged to include multiple PIs on the application. Mechanism of Support. This FOA will utilize the U01 (cooperative agreement) grant mechanism. Applicants will submit a single application organized into three phases, beginning with Phase I which will have technology development to generate induced pluripotent stem (iPS) cells from human samples and differentiate these iPS cells into tissues relevant to heart, lung, blood and sleep (HLBS) diseases. Phase II involves ramping up the technology developed in Phase I for high throughput generation of differentiated cells from iPS cells in population samples. Phase III will utilize technology developed in Phases I and II to test genome wide association study (GWAS) generated functional hypotheses in cell-based models of disease. Applicants may propose Phases I to III or II to III depending on the current state of iPS generation and cell type differentiation technology needed to meet their specific aims. Inclusion of Phase I is dependent on the validation and reproducibility of cell differentiation protocols for the specific cell type(s) proposed in the application. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-11-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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