The National Institute on Aging (NIA) and National Cancer Institute (NCI) are offering this NIH Exploratory/Developmental (R21) grant. This grant is for identifying and characterizing novel molecular targets within the mTOR (mammalian target of rapamycin) pathway. The goal is to promote healthy aging and extend healthspan (NIA interest), and to identify dietary constituents modulating mTOR for cancer prevention (NCI interest). Research can utilize diverse approaches, including medicinal chemistry, in vitro assays, and studies in lower organisms or mammalian models, supporting innovative investigations into this critical signaling network.
Opportunity ID: 53628
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-10-164 |
| Funding Opportunity Title: | Identification and Characterization of Molecular Targets Within the mTOR Pathway With Potential to Impact Healthspan and Lifespan (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 09, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 17, 2013 |
| Current Closing Date for Applications: | May 17, 2013 |
| Archive Date: | Jun 17, 2013 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments For profit organizations other than small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This FOA issued by the National Institute on Aging and the National Cancer Institute encourages grant applications focused on: 1) identifying novel targets within the mTOR (mammalian target of rapamycin) signaling network, the manipulation of which has the potential to promote healthy aging, i.e. extend health span in the aged (NIA interest); and 2) identifying and characterizing dietary constituents that modulate the mTOR pathway and promote cancer prevention (NCI interest). Identification and characterization of targets can utilize a wide range of approaches, including medicinal chemistry, in vitro assays, and studies in lower organisms or mammalian models. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) award mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-10-164.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00017890 | May 16, 2010 | Nov 02, 2010 | View | |
| ADOBE-FORMS-B1 | Supersedes ADOBE-FORMS-B | PKG00022281 | Nov 02, 2010 | May 17, 2013 | View |
Package 1
Mandatory forms
53628 RR_SF424_1_2-1.2.pdf
53628 PerformanceSite_1_3-1.3.pdf
53628 RR_OtherProjectInfo_1_2-1.2.pdf
53628 RR_KeyPersonExpanded_1_2-1.2.pdf
53628 PHS398_CoverPageSupplement_1_4-1.4.pdf
53628 PHS398_ResearchPlan_1_3-1.3.pdf
53628 PHS398_Checklist_1_3-1.3.pdf
Optional forms
53628 PHS_CoverLetter_1_2-1.2.pdf
53628 PHS398_ModularBudget-1.1.pdf
53628 RR_Budget-1.1.pdf
53628 RR_SubawardBudget-1.2.pdf
Package 2
Mandatory forms
53628 RR_SF424_1_2-1.2.pdf
53628 RR_OtherProjectInfo_1_3-1.3.pdf
53628 RR_KeyPersonExpanded_1_2-1.2.pdf
53628 PerformanceSite_1_4-1.4.pdf
53628 PHS398_ResearchPlan_1_3-1.3.pdf
53628 PHS398_CoverPageSupplement_1_4-1.4.pdf
53628 PHS398_Checklist_1_3-1.3.pdf
Optional forms
53628 RR_Budget-1.1.pdf
53628 RR_SubawardBudget-1.2.pdf
53628 PHS_CoverLetter_1_2-1.2.pdf
53628 PHS398_ModularBudget-1.1.pdf
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